Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
BMC Ophthalmol. 2013 Aug 8;13(1):42. doi: 10.1186/1471-2415-13-42.
To report a case of bilateral optic disc oedema and associated optic neuropathy in the setting of FOLFOX chemotherapy.
A case of a 57-year-old male being treated with FOLFOX chemotherapy for stage 3B colorectal cancer, who developed bilateral optic disc oedema and associated left sided optic neuropathy is described. The patient presented following cycles 7, 8 and 9 of chemotherapy with a history of bilateral simultaneous intermittent inferior altitudinal field defects. These episodes progressed to bilateral optic nerve oedema and a subsequent left sided optic neuropathy. The patient's symptoms and oedema regressed with discontinuation of chemotherapy.
This is the first report suggesting a vasospastic role of 5-fluoruracil in 5-FU associated optic neuropathy. It highlights that 5-FU may have the potential to cause arterial vasospasm outside the cardiac vasculature, resulting in end-organ optic nerve ischaemia.
报告一例在 FOLFOX 化疗中出现双侧视盘水肿和相关的视神经病变。
描述了一名 57 岁男性在接受 FOLFOX 化疗治疗 3B 期结直肠癌时出现双侧视盘水肿和左侧视神经病变的情况。该患者在化疗第 7、8 和 9 周期后出现双侧同时间歇性下方垂直视野缺损的病史。这些发作进展为双侧视神经水肿和随后的左侧视神经病变。患者的症状和水肿在停止化疗后消退。
这是首例报告提示 5-氟尿嘧啶在 5-FU 相关视神经病变中具有血管痉挛作用。它强调了 5-FU 可能有潜力在外周血管之外引起动脉血管痉挛，导致终末器官视神经缺血。
