Agarwal Paras, Khera Manav
Ophthalmology, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, GBR.
Cureus. 2024 Oct 31;16(10):e72754. doi: 10.7759/cureus.72754. eCollection 2024 Oct.
Bilateral successive anterior ischaemic optic neuropathy (AION) episodes are uncommon occurrences with a short list of differential diagnoses. We present the case of a 75-year-old male who developed bilateral consecutive non-arteritic AION after commencing 5-fluorouracil (5-FU) chemotherapy. The case report describes a temporal sequence of events with a halt in the progression of signs and symptoms upon cessation of treatment with this agent. Our patient demonstrated preexisting cardiovascular risk factors that were medically well controlled, as evidenced by laboratory results and blood pressure measurements. We reaffirm the current evidence that postulates an association between 5-FU use and arterial vasospasm in blood vessels predisposed to narrowing resulting in prolonged ischaemia to the optic nerve head.
双侧相继发生的前部缺血性视神经病变（AION）发作并不常见，鉴别诊断范围较窄。我们报告一例75岁男性病例，该患者在开始5-氟尿嘧啶（5-FU）化疗后发生双侧连续性非动脉炎性AION。该病例报告描述了一系列按时间顺序发生的事件，在停用该药物治疗后，体征和症状的进展停止。我们的患者存在已得到良好医学控制的既往心血管危险因素，实验室检查结果和血压测量结果均可证明。我们再次确认了当前的证据，即5-FU的使用与易发生狭窄的血管中的动脉血管痉挛之间存在关联，这会导致视神经乳头长时间缺血。
