一名患有视盘玻璃膜疣的患者在接受结肠癌FOLFOX化疗时发生前部缺血性视神经病变：奥卡姆剃刀原理与希卡姆格言的价值

Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Rom J Ophthalmol. 2019 Apr-Jun;63(2):174-177.

A 53-year-old male developed acute diminution of vision in his right eye while on FOLFOX chemotherapy for stage C colon cancer. Examination revealed bilateral optic nerve head swelling with flame shaped hemorrhages over the right optic disc and anomalous left retinal vasculature. Computed tomography scan of the brain and orbit revealed no cerebral pathology, however bilateral optic disc drusen (ODD) was suspected. B scan ultrasonography confirmed the presence of bilateral ODD. Fluorescein angiography showed early hypofluorescence of the right optic disc with bilateral late disc staining and a diagnosis of right anterior ischemic optic neuropathy (AION) with bilateral ODD was made. A literature review was performed and possible mechanisms for the development of AION in this case were discussed.

一名53岁男性在接受FOLFOX化疗治疗C期结肠癌时，右眼视力急性下降。检查发现双侧视神经乳头肿胀，右侧视盘有火焰状出血，左侧视网膜血管异常。脑部和眼眶的计算机断层扫描未发现脑部病变，但怀疑双侧存在视盘小疣（ODD）。B超检查证实双侧存在ODD。荧光素血管造影显示右侧视盘早期低荧光，双侧晚期视盘染色，诊断为右侧前部缺血性视神经病变（AION）伴双侧ODD。进行了文献综述，并讨论了该病例中AION发生的可能机制。