Laboratory of Virology and Swiss National Reference Center for Influenza, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva and Medical School, University of Geneva, Geneva, Switzerland.
Clin Microbiol Infect. 2014 Jan;20(1):O58-64. doi: 10.1111/1469-0691.12324. Epub 2013 Aug 8.
Indirect transmission of the influenza virus via finger contamination with respiratory mucus droplets has been hypothesized to contribute to transmission in the community. Under laboratory conditions, influenza-infected respiratory droplets were reconstituted as close as possible to natural conditions. We investigated experimentally the survival of influenza A (H3N2) and A (H1N1)pdm09 viruses on human fingers. Infectious virus was easily recoverable on all fingers 1 min after fingertip contamination but then decreased very rapidly. After 30 min, infectious virus was detectable in only a small minority of subjects. Infectious viruses were detected for a longer period of time when droplets of larger size containing a higher number of particles were tested or when the viral concentration increased. A rapid decrease in infectiousness was observed when droplet integrity was disrupted. Our findings could help to set up the promotion of hand hygiene to prevent influenza hand contamination.
流感病毒通过手指污染呼吸道飞沫的间接传播被认为有助于社区传播。在实验室条件下，将感染流感的呼吸道飞沫尽可能地恢复到自然状态。我们通过实验研究了甲型流感（H3N2）和 A（H1N1）pdm09 病毒在人手指上的存活情况。在指尖污染 1 分钟后，所有手指上都很容易检测到具有感染性的病毒，但随后迅速下降。30 分钟后，只有少数受检者可检测到具有感染性的病毒。当测试更大颗粒数更多的飞沫时，或者当病毒浓度增加时，可检测到具有感染性的病毒的时间会更长。当飞沫完整性被破坏时，传染性迅速下降。我们的研究结果有助于建立促进手部卫生以防止流感手部污染的措施。
