甲状旁腺激素在维生素 D 不足个体的血压调节中具有重要作用。
Parathyroid hormone has an important role in blood pressure regulation in vitamin D-insufficient individuals.
机构信息
Nutrition Department, School of Public Health, University of Sao Paulo, Brazil.
出版信息
Nutrition. 2013 Sep;29(9):1147-51. doi: 10.1016/j.nut.2013.03.022.
OBJECTIVE
The aim of the present study was to evaluate whether vitamin D status is related to blood pressure (BP) in adults.
METHODS
We evaluated the relationship between vitamin D status, intact parathyroid hormone (iPTH) and BP in 332 adults. Anthropometric measurements, BP, and a fasting blood sample was obtained. Participants were stratified into the following BP categories: 1) normal BP; 2) high BP; 3) normal BP through medication. Vitamin D insufficiency was defined as 25-hydroxvitamin D ≤ 75 nmol/L; high iPTH as > 65 pg/mL. The relationships between vitamin D status, iPTH and BP were adjusted for body mass index, waist circumference, blood lipids, physical activity, and sunscreen use.
RESULTS
No differences in prevalences of vitamin D insufficiency and high iPTH were observed among BP groups. No significant association was observed between BP and vitamin D status. Positive correlations were observed between iPTH and systolic BP (r = 0.168; P = 0.002) and between iPTH and diastolic BP (r = 0.168; P = 0.002). iPTH remained correlated with BP even with adjustments.
CONCLUSIONS
The present study contributes to the understanding of calcemic hormones and BP regulation.
目的
本研究旨在评估维生素 D 状态是否与成年人的血压（BP）有关。
方法
我们评估了 332 名成年人的维生素 D 状态、完整甲状旁腺激素（iPTH）与 BP 之间的关系。测量了人体测量学指标、BP，并采集了空腹血样。将参与者分为以下 BP 类别：1）正常 BP；2）高 BP；3）通过药物治疗使 BP 正常。将 25-羟维生素 D≤75nmol/L 定义为维生素 D 不足；将 iPTH>65pg/mL 定义为高 iPTH。对 BMI、腰围、血脂、体力活动和防晒霜使用等因素进行调整后，评估了维生素 D 状态、iPTH 与 BP 之间的关系。
结果
在 BP 组中，维生素 D 不足和高 iPTH 的患病率没有差异。BP 与维生素 D 状态之间没有显著相关性。iPTH 与收缩压呈正相关（r=0.168；P=0.002），与舒张压呈正相关（r=0.168；P=0.002）。即使进行了调整，iPTH 与 BP 仍然相关。
结论
本研究有助于了解钙调节激素与 BP 调节之间的关系。
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