Carmelli D, Swan G E, Robinette D, Fabsitz R R
SRI International, Menlo Park, California.
Acta Genet Med Gemellol (Roma). 1990;39(1):91-8. doi: 10.1017/s0001566000005602.
This study examines the heritability of cigarette smoking, alcohol, and coffee consumption in 4,960 adult, male twin pairs (2,390 MZ and 2,570 DZ pairs) participants in an epidemiologic survey of the NAS-NRC Twin Registry conducted in the USA during 1972-73. Heritability estimates for smoking, alcohol and coffee use were calculated both before and after adjustment for shared variance between these behaviors and other demographic characteristics including socioeconomic status and an occupational adjustment score. The objective of the analysis was to determine the impact of adjustment for covariates on heritability estimates of smoking, alcohol and coffee use. Before adjustment, genetic effects in smoking, alcohol and coffee use accounted for 53%, 36%, and 45% of the variance, respectively. After adjustment, the corresponding estimates were 35%, 29%, and 36%. The fact that these estimates remained significant after adjustment for covariates leads to increased confidence about the role of genetic factors in substance use behaviors.
本研究调查了参与1972 - 73年在美国进行的美国国家科学院-国家研究委员会双胞胎登记处流行病学调查的4960对成年男性双胞胎（2390对同卵双胞胎和2570对异卵双胞胎）中吸烟、饮酒和喝咖啡行为的遗传性。在对这些行为与包括社会经济地位和职业调整分数在内的其他人口统计学特征之间的共享方差进行调整之前和之后，分别计算了吸烟、饮酒和喝咖啡行为的遗传率估计值。分析的目的是确定协变量调整对吸烟、饮酒和喝咖啡行为遗传率估计值的影响。调整前，吸烟、饮酒和喝咖啡行为的遗传效应分别占方差的53%、36%和45%。调整后，相应的估计值分别为35%、29%和36%。在对协变量进行调整后这些估计值仍然显著这一事实，增强了我们对遗传因素在物质使用行为中作用的信心。
