Department of Head and Neck Surgery, Medical School of the University of São Paulo, SP, Brazil.
Braz J Otorhinolaryngol. 2013 Aug;79(4):500-4. doi: 10.5935/1808-8694.20130089.
Despite the low incidence, diagnostic and therapeutic advances, hypopharyngeal cancer still has high mortality.
To evaluate retrospectively the epidemiological profile and response to surgery and radiation/chemotherapy of patients with hypopharyngeal cancer.
We reviewed the medical records of 114 patients treated between 2002 and 2009 in a tertiary hospital with histopathological diagnosis of squamous cell carcinoma.
The mean age of the patients was 57 years, 94.7% were males and 5.3% females, 98.2% were smokers and 92% consumed alcohol; 72% are illiterate or did not complete first grade schooling. The main complaints were: neck node (28%), pain and dysphagia (22%), odynophagia (12.2%), dysphonia (7.8%). The clinical staging was: I (1.7%), II (3.5%), III (18.4%), IV (76.3%). The treatment was carried out with radiotherapy and chemotherapy alone in 35%, with mean 2-year survival of 20% and 5-year survival of 18%; surgery followed by radiotherapy and chemotherapy in 22.8% with 2-year survival of 60.0% and 5 years of 55.0%; chemotherapy alone in 2.6%, and 39.4% without treatment.
Most patients already had advanced clinical stages and independent of the treatment option, had a low survival rate, confirming the poor prognosis of this neoplasm.
尽管发病率低，但在诊断和治疗方面取得了进展，下咽癌的死亡率仍然很高。
回顾性评估下咽癌患者的流行病学特征以及手术和放化疗的反应。
我们回顾了 2002 年至 2009 年在一家三级医院接受治疗的 114 例经组织病理学诊断为鳞状细胞癌的患者的病历。
患者的平均年龄为 57 岁，94.7%为男性，5.3%为女性，98.2%为吸烟者，92%为饮酒者；72%为文盲或未完成一年级学业。主要症状为：颈部淋巴结（28%）、疼痛和吞咽困难（22%）、咽痛（12.2%）、声音嘶哑（7.8%）。临床分期为：I 期（1.7%）、II 期（3.5%）、III 期（18.4%）、IV 期（76.3%）。治疗方式为单独放疗和化疗的占 35%，2 年生存率为 20%，5 年生存率为 18%；手术联合放疗和化疗的占 22.8%，2 年生存率为 60.0%，5 年生存率为 55.0%；单独化疗的占 2.6%，39.4%未接受治疗。
大多数患者已经处于晚期临床阶段，无论选择何种治疗方案，生存率都较低，这证实了这种肿瘤的预后较差。
