Department of Human Physiology, Egypt.
Int J Gen Med. 2013 Jul 29;6:631-6. doi: 10.2147/IJGM.S46953. Print 2013.
Whatever the initial stimulus for the exercise-induced bronchoconstriction (EIB) observed in asthmatic patients after exercise, the final effect is release of bronchoactive mediators, especially cysteinyl leukotrienes. Exercise rehabilitation training programs have been reported to protect against EIB. The exact mechanism(s) involved are not well understood. However, this protective effect may be related to adaptation and better coordination during exercise, depletion of cysteinyl leukotrienes, and/or a sluggish cysteinyl leukotriene response to exercise. The aim of the present work was to test the hypothesis that improvement in the incidence and severity of post-exercise bronchoconstriction after a rehabilitation training program is related to a change in leukotriene levels in response to exercise.
Twenty asthmatic children aged 6-12 years and known to develop EIB were enrolled in an exercise training program for 12 weeks. The severity and incidence of EIB before and after training was assessed. Baseline and post-exercise sputum cysteinyl leukotriene levels were assessed before and after the training program.
The training program offered significant protection against EIB with a concomitant decrease in sputum cysteinyl leukotriene levels in response to exercise.
A training program can result in depletion and/or a sluggish cysteinyl leukotriene response to exercise and may be responsible for the protective effect of training programs on EIB. It is recommended to use an exercise rehabilitation training program as a complementary tool in the management of bronchial asthma, especially EIB.
无论运动诱发的支气管收缩（EIB）在运动后哮喘患者中最初的刺激因素是什么，最终的结果都是支气管活性介质的释放，尤其是半胱氨酰白三烯。运动康复训练计划已被报道可预防 EIB。其确切机制尚不清楚。然而，这种保护作用可能与运动过程中的适应性和更好的协调性、半胱氨酰白三烯的耗竭以及/或运动后半胱氨酰白三烯反应迟钝有关。本研究的目的是检验以下假设，即在康复训练计划后，运动后支气管收缩的发生率和严重程度的改善与运动后白三烯水平的变化有关。
20 名年龄在 6-12 岁的已知发生 EIB 的哮喘儿童参加了为期 12 周的运动训练计划。在训练前后评估 EIB 的严重程度和发生率。在训练计划前后评估基础和运动后痰半胱氨酰白三烯水平。
该训练计划可显著预防 EIB，并伴有运动后痰半胱氨酰白三烯水平的下降。
训练计划可导致半胱氨酰白三烯耗竭和/或反应迟钝，这可能是训练计划对 EIB 具有保护作用的原因。建议将运动康复训练计划作为支气管哮喘（尤其是 EIB）管理的辅助工具。
