Professor of Medical Physics, Radiobiology & Radiation Protection Department, School of Allied Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; ; The Center for Research in Radiological Sciences, School of Allied Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran;
Dose Response. 2012 Jul 2;11(2):281-92. doi: 10.2203/dose-response.12-010.Mortazavi. Print 2013.
The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1(st) phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2(nd) phase, 30 male rats were divided into 2 groups of 15 animals. The 1(st) group received microwave exposure. The 2(nd) group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response.
本研究旨在探讨预先照射微波对诱导放射适应反应的影响。在研究的第 1 阶段，将 110 只雄性小鼠分为 8 组。这些组的动物接受/假照射微波、低剂量率γ射线或两者照射 5 天。第 6 天，动物接受致死剂量（LD）照射。在第 2 阶段，将 30 只雄性大鼠分为 2 组，每组 15 只。第 1 组接受微波照射。第 2 组（对照组）接受相同的 LD，但在 LD 之前没有治疗。第 5 天，所有动物均全身接受 LD 照射。与仅接受 LD 照射γ射线的动物相比，预先接受微波（p=0.02）、低剂量率γ射线（p=0.001）或这两种物理适应剂量照射的动物的生存率有统计学显著差异（p=0.003）。同样，观察到对照组和实验组大鼠生存率之间存在统计学显著差异。总之，这些实验表明，暴露于微波辐射可能会诱导出显著的生存适应反应。
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