Hackbarth C J, Chambers H F, Sande M A
Antimicrob Agents Chemother. 1986 Apr;29(4):611-3. doi: 10.1128/AAC.29.4.611.
Because rifampin-resistant strains of Staphylococcus aureus emerge during monotherapy with this drug, a search was made for potentially useful companion drugs. Bactericidal titers of spiked serum were determined, and time kill studies were performed for 10 strains of methicillin-susceptible S. aureus. We tested rifampin in combination with nafcillin, vancomycin, clindamycin, pefloxacin, ciprofloxacin, trimethoprim, teicoplanin, or erythromycin. The bactericidal activity of nafcillin, vancomycin, and teicoplanin was significantly reduced (P less than 0.05) when rifampin was added to the drug regimen. In contrast, the addition of rifampin to clindamycin or erythromycin significantly increased bactericidal activity as measured by both bactericidal titers in serum and 6-h killing rates (P less than 0.02). Bactericidal activity in serum was also increased by the addition of rifampin to trimethoprim, but rifampin-resistant strains emerged with this combination.
由于在使用该药物进行单药治疗期间会出现耐利福平的金黄色葡萄球菌菌株，因此人们寻找了可能有用的联合用药。测定了加样血清的杀菌效价，并对10株甲氧西林敏感的金黄色葡萄球菌进行了时间杀菌研究。我们测试了利福平与萘夫西林、万古霉素、克林霉素、培氟沙星、环丙沙星、甲氧苄啶、替考拉宁或红霉素的联合使用情况。当在药物治疗方案中加入利福平时，萘夫西林、万古霉素和替考拉宁的杀菌活性显著降低（P小于0.05）。相比之下，将利福平加入克林霉素或红霉素中，通过血清杀菌效价和6小时杀菌率测定，杀菌活性均显著增加（P小于0.02）。将利福平加入甲氧苄啶中血清杀菌活性也会增加，但该联合用药会出现耐利福平菌株。
