Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States.
Mol Cell Endocrinol. 2014 Jan 25;382(1):642-651. doi: 10.1016/j.mce.2013.07.031. Epub 2013 Aug 8.
Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a large multi-domain protein that has been shown to modulate an increasing number of pathways and biological processes. The first reports describing the cloning and characterization of PELP1 showed that it was an estrogen receptor coactivator. PELP1 has now been shown to be a coregulator for a growing number of transcription factors. Furthermore, recent reports have shown that PELP1 is a member of chromatin remodeling complexes. In addition to PELP1 nuclear functions, it has been shown to have cytoplasmic signaling functions as well. In the cytoplasm PELP1 acts as a scaffold molecule and mediates rapid signaling from growth factor and hormone receptors. PELP1 signaling ultimately plays a role in cancer biology by increasing proliferation and metastasis, among other cellular processes. Here we will review (1) the cloning and characterization of PELP1 expression, (2) interacting proteins, (3) PELP1 signaling, and (4) PELP1-mediated biology.
脯氨酸、谷氨酸和亮氨酸丰富蛋白 1（PELP1）是一种大型多功能蛋白，已被证明能调节越来越多的途径和生物过程。最早描述 PELP1 克隆和特征的报告表明，它是一种雌激素受体共激活剂。现在已经证明 PELP1 是越来越多转录因子的共调节剂。此外，最近的报告表明 PELP1 是染色质重塑复合物的成员。除了 PELP1 的核功能外，它还具有细胞质信号功能。在细胞质中，PELP1 作为支架分子，介导生长因子和激素受体的快速信号转导。PELP1 信号最终通过增加增殖和转移等细胞过程在癌症生物学中发挥作用。在这里，我们将回顾（1）PELP1 表达的克隆和特征，（2）相互作用蛋白，（3）PELP1 信号转导，和（4）PELP1 介导的生物学。
