DATAPLAMT, Museu de História Natural e Jardim Botânico, Universidade Federal de Minas Gerais, Brazil; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J Ethnopharmacol. 2013 Oct 7;149(3):790-6. doi: 10.1016/j.jep.2013.08.004. Epub 2013 Aug 9.
Bitter tasting plant species are used as tonics and have been previously used to treat intermittent fevers in Brazil, the principal symptom of malaria. Many of these species were named quina and were used as substitutes of Cinchona spp., the source of quinine.
To present data on these bitter species named quina and to discuss their potential as sources of bioactive substances.
Data about the plants were obtained from a survey of the literature and documents written by early naturalists and clinical doctors living in the 18th and 19th centuries in Brazil. Correlated pharmacological studies were obtained from different scientific databases.
A total of 29 species were recorded. The largest number of species belonged to the Rubiaceae family (14), being Remijia ferruginea (A. St.-Hil) DC. the most representative. Strychnos pseudoquina A. St.-Hil. (Loganiaceae), Hortia brasiliana Vand. ex DC. (Rutaceae) and Solanum pseudoquina A. St.-Hil. (Solanaceae) were also frequently mentioned in the historical bibliography. Pharmacological studies have shown the presence of bitter bioactive substances useful to treat digestive disorders and/or with antimalarial activities, in all of the recorded botanic families.
This study shows that several bitter species named quina were used in the past as substitute of Cinchona spp. and studying these plants can lead to the development of new products.
苦味植物被用作补品，以前在巴西被用来治疗间歇性发热，这是疟疾的主要症状。这些物种中的许多被命名为金鸡纳，被用作金鸡纳属（奎宁的来源）的替代品。
介绍这些被命名为金鸡纳的苦味物种的数据，并讨论它们作为生物活性物质来源的潜力。
从对 18 世纪和 19 世纪生活在巴西的早期自然主义者和临床医生撰写的文献和文献的调查中获得有关植物的数据。从不同的科学数据库中获得相关的药理学研究。
共记录了 29 种物种。数量最多的物种属于茜草科（Rubiaceae）（14 种），其中最具代表性的是 Remijia ferruginea（A. St.-Hil）DC。Strychnos pseudoquina A. St.-Hil.（Loganiaceae）、Hortia brasiliana Vand. ex DC.（芸香科）和 Solanum pseudoquina A. St.-Hil.（茄科）在历史文献中也经常被提及。药理学研究表明，在所有记录的植物科中，都存在苦味生物活性物质，可用于治疗消化紊乱和/或具有抗疟活性。
本研究表明，过去有几种被命名为金鸡纳的苦味植物被用作金鸡纳属的替代品，研究这些植物可以开发新产品。
