Bennett I C, McCaffrey J F, McCaffrey E, Wyatt B
Department of Surgery, University of Queensland, Royal Brisbane Hospital, Herston, Australia.
Br J Cancer. 1990 Jan;61(1):142-6. doi: 10.1038/bjc.1990.29.
It has been suggested that the percentage of non-protein-bound or free oestradiol (E2) is abnormally high in patients with breast cancer. In this study, the serum oestradiol profiles of a large group of women were analysed to determine whether a significant correlation could be found between serum oestradiol and various breast diseases. In addition oestradiol levels were measured in relation to sex hormone binding globulin (SHBG), albumin levels, oestrogen receptor status and family history of breast cancer. Serum samples were taken from a total of 300 women who had either no breast disease, benign breast disease or breast cancer. The percentage of free oestradiol was found to be highest in women with breast cancer, lowest in the control group and intermediate for the women with benign breast disease. These differences were most marked in post-menopausal women. The absolute values for total and free oestradiol were not statistically different in the three groups studied. There did not appear to be a correlation between oestrogen receptor (ER) concentration in breast cancer tissue and free E2 percentage levels. Women who had a family history of breast cancer did not appear to have higher percentage levels of free E2 than those with no such history. The presence of elevated proportions of free oestradiol in the serum of women with breast cancer may be significant in regard to understanding the aetiology of breast neoplasia. There also may be important implications for the use of this measurement in the earlier diagnosis and detection of breast cancer.
有人提出，乳腺癌患者中非蛋白结合或游离雌二醇（E2）的百分比异常高。在本研究中，分析了一大组女性的血清雌二醇谱，以确定血清雌二醇与各种乳腺疾病之间是否存在显著相关性。此外，还测量了雌二醇水平与性激素结合球蛋白（SHBG）、白蛋白水平、雌激素受体状态以及乳腺癌家族史的关系。从总共300名无乳腺疾病、患有良性乳腺疾病或乳腺癌的女性中采集血清样本。发现游离雌二醇的百分比在乳腺癌女性中最高，在对照组中最低，在患有良性乳腺疾病的女性中处于中间水平。这些差异在绝经后女性中最为明显。在所研究的三组中，总雌二醇和游离雌二醇的绝对值在统计学上没有差异。乳腺癌组织中的雌激素受体（ER）浓度与游离E2百分比水平之间似乎没有相关性。有乳腺癌家族史的女性的游离E2百分比水平似乎并不高于没有这种家族史的女性。乳腺癌女性血清中游离雌二醇比例升高可能对理解乳腺肿瘤的病因具有重要意义。这一测量方法在乳腺癌的早期诊断和检测中也可能具有重要意义。
