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新生物学:通往临床心脏病学的桥梁。

The new biology: a bridge to clinical cardiology.

作者信息

Louridas Ge, Lourida Kg

机构信息

Cardiology Department, University General Hospital AHEPA , Aristotle University of Thessaloniki, Greece.

出版信息

Hippokratia. 2012 Apr;16(2):106-12.

Abstract

The recent advances in the biological research have produced new biological disciplines with clinical applications in medicine and cardiology. The integration of multilevel biological data and the connection with the clinical practice reveal the potential of personalized medicine and nanotechnology with future implications for prognosis, diagnosis and management. In the post-genomic time period the new disciplines, systems biology, synthetic biology and translational medicine are emerging as significant research areas in biology and medicine with extension in the field of clinical medicine and cardiology. These disciplines, with their predictive, preventive and therapeutic potential, are formulating the concept of personalized management, with patient's energetic involvement and participation in the diagnosis and treatment. Personalized medicine and cardiology, using biomarkers as health and disease indicators, encourage drug development and direct towards a better molecular comprehension of disease processes.

摘要

生物学研究的最新进展催生了在医学和心脏病学中有临床应用的新生物学学科。多层次生物学数据的整合以及与临床实践的联系揭示了个性化医学和纳米技术的潜力,对预后、诊断和管理具有未来意义。在后基因组时代,新学科系统生物学、合成生物学和转化医学正在成为生物学和医学中的重要研究领域,并在临床医学和心脏病学领域得到拓展。这些学科具有预测、预防和治疗潜力,正在形成个性化管理的概念,让患者积极参与诊断和治疗。个性化医学和心脏病学利用生物标志物作为健康和疾病指标,鼓励药物研发,并朝着更好地从分子层面理解疾病过程的方向发展。

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本文引用的文献

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Systems biology and the future of medicine.系统生物学与未来医学。
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Synthetic biology moving into the clinic.合成生物学进入临床应用。
Science. 2011 Sep 2;333(6047):1248-52. doi: 10.1126/science.1206843.
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