Department of Dermatology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA, 15213, U.S.A.
Br J Dermatol. 2013 Dec;169(6):1188-97. doi: 10.1111/bjd.12578.
Gene expression studies of cutaneous T-cell lymphoma (CTCL) span a decade, yet the pathogenesis is poorly understood and diagnosis remains a challenge. This review examines the varied approaches to gene expression analysis of CTCL, with emphasis on cell populations, control selection and expression data collection. Despite discordant results, several dysregulated genes have been identified across multiple studies, including PLS3, KIR3DL2, TWIST1 and STAT4. Here, we provide an overview of the most consistently expressed genes across different studies and bring them together through common pathways biologically relevant to CTCL. Four pathways - evasion of activation-induced cell death, T helper 2 lymphocyte differentiation, transforming growth factor-β receptor expression, and tumour necrosis factor receptor ligands - appear to encompass the most frequently affected genes, hypothetically providing insight into the disease pathogenesis.
皮肤 T 细胞淋巴瘤 (CTCL) 的基因表达研究跨越了十年，但发病机制仍不清楚，诊断仍然是一个挑战。本综述探讨了 CTCL 基因表达分析的各种方法，重点介绍了细胞群体、对照选择和表达数据收集。尽管结果不一致，但在多项研究中已经确定了几个失调的基因，包括 PLS3、KIR3DL2、TWIST1 和 STAT4。在这里，我们提供了不同研究中最一致表达的基因的概述，并通过与 CTCL 生物学相关的共同途径将它们汇集在一起。四个途径 - 逃避激活诱导的细胞死亡、辅助性 T 淋巴细胞 2 分化、转化生长因子-β受体表达和肿瘤坏死因子受体配体 - 似乎包含了最常受影响的基因，这为疾病发病机制提供了假设性的见解。
