恶性疾病中的慢性炎症和免疫限制。
Chronic inflammation and immunologic-based constraints in malignant disease.
机构信息
Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Immunotherapy. 2011 Oct;3(10):1265-74. doi: 10.2217/imt.11.113.
Abstract
Acute inflammatory reactions benefit the host by supporting the effective clearance of pathogens and fostering wound healing, in addition to other self-preservative processes. However, when the inflammatory program is not resolved, becoming chronic in nature, it creates an environment conducive to cancer development and progression. Therefore, minimizing exposure to risk factors that contribute to chronic inflammation and reconditioning the host towards a state of (at least locoregional) acute inflammation would meaningfully impact cancer incidence and its treatment, respectively. Regarding cancer therapy, combinational treatments that both disrupt chronic inflammation and install specific adaptive type I immunity are predicted to enhance quality of life and extend the overall survival of patients.
摘要
急性炎症反应通过支持有效清除病原体和促进伤口愈合，以及其他自我保护过程，对宿主有益。然而，当炎症程序未得到解决，变得具有慢性特征时，它会创造一个有利于癌症发展和进展的环境。因此，最大限度地减少导致慢性炎症的风险因素的暴露，并使宿主向（至少局部）急性炎症状态重新调整，将分别对癌症发病率和治疗产生有意义的影响。关于癌症治疗，预测联合治疗既能破坏慢性炎症又能建立特定的适应性 I 型免疫，将提高患者的生活质量并延长其总生存期。
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