Diagn Pathol. 2013 Aug 9;8:135. doi: 10.1186/1746-1596-8-135.
Classical Hodgkin lymphoma (CHL) is a lymphoproliferative disorder that has a bimodal age distribution, affecting young and elderly individuals, and is curable in more than 90% of patients. Here we report the coexistence of cutaneous CHL and malignant melanoma as the presentation of papules and a plaque, in an individual with remote history of systemic CHL. One of the biopsies showed a mononuclear cell infiltrate with Reed-Sternberg (RS) like cells that were positive for CD30 and CD15, but negative for CD45. A second concurrent biopsy showed an atypical melanocytic proliferation with significant pagetoid spreading and diffuse Melan-A staining. Based on morphology alone, it is almost impossible to distinguish CHL from other primary cutaneous lymphoproliferative disorders, such as CD30+ lymphoproliferative disorder (lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma), or even tumor stage mycosis fungoides when the epidermotropism is minimal. Additionally, bizarre melanocytic cells can also appear similar to RS cells. Our case illustrates the first case report of malignant melanoma and CHL in a patient presenting simultaneously.
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经典霍奇金淋巴瘤（CHL）是一种淋巴增生性疾病，具有双峰年龄分布，影响年轻人和老年人，并且 90%以上的患者可以治愈。在这里，我们报告了皮肤 CHL 和恶性黑色素瘤同时存在，表现为丘疹和斑块，在一个有系统性 CHL 病史的个体中。其中一个活检显示单核细胞浸润，伴有 Reed-Sternberg（RS）样细胞，CD30 和 CD15 阳性，但 CD45 阴性。第二个同时进行的活检显示出不典型的黑色素细胞增生，有明显的 pagetoid 扩散和弥漫性 Melan-A 染色。仅从形态学上，几乎不可能将 CHL 与其他原发性皮肤淋巴增生性疾病区分开来，例如 CD30+淋巴增生性疾病（淋巴样丘疹病（LyP）和原发性皮肤间变性大细胞淋巴瘤），甚至当表皮亲嗜性最小时，肿瘤期蕈样真菌病。此外，奇异的黑色素细胞也可能类似于 RS 细胞。我们的病例首次报告了恶性黑色素瘤和 CHL 在一个同时出现的患者中。
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