Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Opt Lett. 2013 Jun 15;38(12):2038-40. doi: 10.1364/OL.38.002038.
We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also show that continuous wave or direct time gate approaches to fluorescence tomography are unable to achieve this separation, indicating the unique advantage of a decay-amplitude-based approach for tomographic lifetime multiplexing with time domain data.
我们证明了基于渐近寿命的荧光层析成像可以定位远低于混浊介质漫射点扩散函数的多个寿命目标。这是由于在渐近极限下对时域正问题进行完全对角化而成为可能。我们还表明，连续波或直接时间门荧光层析成像方法无法实现这种分离，这表明基于衰减幅度的方法在使用时域数据进行层析成像寿命复用方面具有独特的优势。
