Department of Gastroenterology, Technion-Israel Institute of Technology, Haifa, Israel.
Endoscopy. 2013 Sep;45(9):697-702. doi: 10.1055/s-0033-1344395. Epub 2013 Aug 12.
Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed with this technique. We aimed to establish the feasibility, usability, and safety of a novel colonoscopy platform featuring full-spectrum endoscopy (FUSE).
This was a prospective, single-center pilot and feasibility study. In total, 50 individuals, ages 18 - 70 years, underwent colonoscopy featuring FUSE (up to 330° field of view) for colorectal cancer screening, polyp surveillance, or diagnostic evaluation. Study end points included success of cecal intubation, time to cecal intubation, withdrawal time, total procedure time, success of therapeutic interventions, adverse events, and endoscopists' subjective evaluation of FUSE.
Cecal intubation was achieved in 50/50 individuals (100 %). Time to cecum (minutes, mean ± SD) was 3.1 ± 1.5 minutes, withdrawal time 12.7 ± 4.4 minutes, and total procedure time 15.3 ± 4.6 minutes. In 22/50 cases (44 %), 26 therapeutic interventions were performed: 19 (73.1 %) biopsies and 7 (26.9 %) polypectomies. No acute or delayed adverse events were observed. Patient satisfaction and endoscopist subjective evaluation were high.
A colonoscopy platform featuring full-spectrum endoscopy appears feasible, usable, and safe. These results represent an important advance in colonoscopy imaging technology and should be further pursued in comparative human studies.
虽然结肠镜检查是检测结直肠腺瘤和癌症的金标准，但该技术仍会遗漏相当一部分腺瘤。我们旨在建立一种新型全光谱内镜（FUSE）结肠镜检查平台的可行性、可用性和安全性。
这是一项前瞻性、单中心的试点和可行性研究。共有 50 名年龄在 18-70 岁之间的个体接受了 FUSE（最大 330°视野）结肠镜检查，用于结直肠癌筛查、息肉监测或诊断评估。研究终点包括盲肠插管成功率、盲肠插管时间、退出时间、总操作时间、治疗干预成功率、不良事件以及内镜医师对 FUSE 的主观评价。
50/50 名个体（100%）成功进行盲肠插管。到达盲肠的时间（分钟，平均值±标准差）为 3.1±1.5 分钟，退出时间为 12.7±4.4 分钟，总操作时间为 15.3±4.6 分钟。在 22/50 例（44%）中，进行了 26 项治疗干预：19 例（73.1%）活检和 7 例（26.9%）息肉切除术。未观察到急性或迟发性不良事件。患者满意度和内镜医师的主观评价均很高。
一种具有全光谱内镜功能的结肠镜检查平台似乎是可行的、可用的且安全的。这些结果代表了结肠镜检查成像技术的重要进展，应在比较性人体研究中进一步探索。
