Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China; Translational Medicine Center of Northern China, Harbin, China.
J Cell Biochem. 2013 Dec;114(12):2637-42. doi: 10.1002/jcb.24631.
Heme oxygenase-1 (HMOX1) is a ubiquitously expressed inducible enzyme that degrades heme to carbon monoxide, biliverdin, and free iron ions. Since 1950, many studies have revealed the role of HMOX1 in reducing the impact of oxidative stress in many types of diseases, such as Alzheimer's disease, heart disease, and the development of tumors. These effects arise as a result of the removal of heme, the biological activities of the products of HMOX1 and the activity of HMOX1 itself. However, HMOX1 has some contradictory effects. The discovery of microRNAs (miRNAs) and their relationship with HMOX1 has provided a new direction for research in this field. Here, we discuss the role of a potential regulatory feedback loop between HMOX1 and miRNAs in pathological processes based on recently published data. We hope to describe a new mechanism for HMOX1 function based on miRNAs to address the contradictory results reported in the literature.
血红素加氧酶-1（HMOX1）是一种广泛表达的诱导型酶，可将血红素降解为一氧化碳、胆红素和游离铁离子。自 1950 年以来，许多研究揭示了 HMOX1 在减轻多种疾病（如阿尔茨海默病、心脏病和肿瘤发展）中氧化应激影响的作用。这些作用源于血红素的去除、HMOX1 产物的生物学活性以及 HMOX1 本身的活性。然而，HMOX1 具有一些矛盾的作用。microRNAs（miRNAs）的发现及其与 HMOX1 的关系为该领域的研究提供了新的方向。在这里，我们根据最近发表的数据讨论了 HMOX1 和 miRNAs 之间潜在的调节反馈环在病理过程中的作用。我们希望基于 miRNAs 描述 HMOX1 功能的新机制，以解决文献中报道的矛盾结果。
