Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ann Rheum Dis. 2014 Nov;73(11):1949-53. doi: 10.1136/annrheumdis-2013-203338. Epub 2013 Aug 12.
To analyse the association between dietary long-chain n-3 polyunsaturated fatty acids (PUFAs) and incidence of rheumatoid arthritis (RA) in middle-aged and older women from the Swedish Mammography Cohort, a population-based prospective study.
Data on diet were collected in 1987 and 1997 via a self-administered food-frequency questionnaire (FFQ). The risk of RA associated with dietary long-chain n-3 PUFAs and fish intake was estimated using Cox proportional hazard regression models, adjusted for age, cigarette smoking, alcohol intake, use of aspirin and energy intake.
Among 32 232 women born 1914-1948, 205 RA cases were identified during a mean follow-up of 7.5 years (1 January 2003 to 31 December 2010; 2 41 120 person-years). An intake of dietary long-chain n-3 PUFAs (FFQ1997) of more than 0.21 g/day (lowest quintile) was associated with a 35% decreased risk of developing RA (multivariable adjusted relative risk (RR) 0.65; 95% CI 0.48 to 0.90) compared with a lower intake. Long-term intake consistently higher than 0.21 g/day (according to both FFQ1987 and FFQ1997) was associated with a 52% (95% CI 29% to 67%) decreased risk. Consistent long-term consumption (FFQ1987 and FFQ1997) of fish ≥1 serving per week compared with<1 was associated with a 29% decrease in risk (RR 0.71; 95% CI 0.48 to 1.04).
This prospective study of women supports the hypothesis that dietary intake of long-chain n-3 PUFAs may play a role in aetiology of RA.
分析瑞典乳腺研究队列（一项基于人群的前瞻性研究）中年及以上女性饮食中长链 n-3 多不饱和脂肪酸（PUFAs）与类风湿关节炎（RA）发病风险的关系。
1987 年和 1997 年通过自我管理的食物频率问卷（FFQ）收集饮食数据。使用 Cox 比例风险回归模型，调整年龄、吸烟、饮酒、阿司匹林使用和能量摄入后，估计饮食长链 n-3 PUFAs 和鱼类摄入与 RA 风险的关系。
在 1914-1948 年出生的 32232 名女性中，在平均 7.5 年（2003 年 1 月 1 日至 2010 年 12 月 31 日；241120 人年）的随访中，共发现 205 例 RA 病例。与低摄入量（FFQ1997 最低五分位数组）相比，每天摄入超过 0.21g 的饮食长链 n-3 PUFAs（FFQ1997），RA 发病风险降低 35%（多变量调整后的相对风险 RR 0.65；95%CI 0.48 至 0.90）。长期摄入（根据 FFQ1987 和 FFQ1997）一直高于 0.21g/天与 RA 发病风险降低 52%（95%CI 29%至 67%）相关。与每周摄入<1 份鱼相比，每周摄入≥1 份鱼与 RA 发病风险降低 29%相关（RR 0.71；95%CI 0.48 至 1.04）。
这项针对女性的前瞻性研究支持了这样一种假说，即饮食中长链 n-3 PUFAs 的摄入可能在 RA 的发病机制中起作用。
