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吸烟、营养及其他可改变的环境因素对类风湿关节炎的影响

[Influence of smoking, nutrition and other modifiable environmental factors on rheumatoid arthritis].

作者信息

Schäfer Christoph, Keyßer Gernot, Reuß-Borst Monika

机构信息

Klinik für Innere Medizin II, Universitätsklinikum Halle, Ernst-Grube-Str. 40, 06120, Halle, Deutschland.

Schwerpunktpraxis für Rheumatologie, Frankenstraße 36, 97708, Bad Bocklet, Deutschland.

出版信息

Z Rheumatol. 2024 Nov;83(9):706-720. doi: 10.1007/s00393-024-01559-y. Epub 2024 Aug 19.

Abstract

Numerous reports in recent years have focused on the influence of environmental factors on rheumatoid arthritis. This article provides an overview of the current study situation on the influence of modifiable environmental factors on the development and course of rheumatoid arthritis. Lifestyle factors, such as cigarette smoking, diet, exercise and body weight can be individually influenced. Factors such as air pollution and socioeconomic status can be influenced by environmental and sociopolitical measures at a public level. Epidemiological studies have identified nicotine abuse, an unhealthy diet and obesity as well as a low level of education and social status as risk factors for the development of rheumatoid arthritis. Numerous factors are also associated with a poorer response to treatment and a worse prognosis. As randomized interventional studies on most environmental factors are hardly feasible, the causal relationship of the individual factors to the incidence and progression of rheumatoid arthritis is difficult to quantify. Nevertheless, the current evidence already enables the provision of appropriate counselling to patients with rheumatoid arthritis with respect to a healthy lifestyle including abstaining from cigarette smoking, maintaining a healthy diet, physical activity and avoiding obesity.

摘要

近年来,众多报告聚焦于环境因素对类风湿关节炎的影响。本文概述了可改变的环境因素对类风湿关节炎的发生发展过程影响的当前研究状况。生活方式因素,如吸烟、饮食、运动和体重,是可以个别加以影响的。空气污染和社会经济地位等因素则可通过公共层面的环境和社会政治措施来加以影响。流行病学研究已确定尼古丁滥用、不健康饮食和肥胖,以及低教育水平和社会地位是类风湿关节炎发病的危险因素。众多因素还与治疗反应较差和预后不良相关。由于针对大多数环境因素进行随机干预研究几乎不可行,因此难以量化各个因素与类风湿关节炎发病率和病情进展之间的因果关系。尽管如此,目前的证据已能够为类风湿关节炎患者提供有关健康生活方式的适当咨询,包括戒烟、保持健康饮食、进行体育活动和避免肥胖。

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