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疟蚊冈比亚按蚊幼虫外周热感觉反应的分子特征。

Molecular characterization of larval peripheral thermosensory responses of the malaria vector mosquito Anopheles gambiae.

机构信息

Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.

出版信息

PLoS One. 2013 Aug 7;8(8):e72595. doi: 10.1371/journal.pone.0072595. Print 2013.

DOI:10.1371/journal.pone.0072595
PMID:23940815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3737131/
Abstract

Thermosensation provides vital inputs for the malaria vector mosquito, Anopheles gambiae which utilizes heat-sensitivity within a broad spectrum of behaviors, most notably, the localization of human hosts for blood feeding. In this study, we examine thermosensory behaviors in larval-stage An. gambiae, which as a result of their obligate aquatic habitats and importance for vectorial capacity, represents an opportunistic target for vector control as part of the global campaign to eliminate malaria. As is the case for adults, immature mosquitoes respond differentially to a diverse array of external heat stimuli. In addition, larvae exhibit a striking phenotypic plasticity in thermal-driven behaviors that are established by temperature at which embryonic development occurs. Within this spectrum, RNAi-directed gene-silencing studies provide evidence for the essential role of the Transient Receptor Potential sub-family A1 (TRPA1) channel in mediating larval thermal-induced locomotion and thermal preference within a discrete upper range of ambient temperatures.

摘要

热感觉为疟疾病媒蚊——冈比亚按蚊提供了重要的输入信息，它利用热敏感性来进行广泛的行为，其中最显著的是定位人类宿主进行吸血。在这项研究中，我们研究了幼虫期冈比亚按蚊的热感觉行为，由于它们必须在水中生活，并且对传播能力很重要，因此作为全球消除疟疾运动的一部分，它们成为了一种有机会的控制媒介的目标。与成蚊一样，不成熟的蚊子对各种外部热刺激有不同的反应。此外，幼虫在热驱动行为方面表现出惊人的表型可塑性，这些行为是由胚胎发育时的温度决定的。在这个范围内，RNAi 定向基因沉默研究为瞬时受体电位亚家族 A1（TRPA1）通道在介导幼虫热诱导运动和在环境温度的离散上限范围内的热偏好方面的重要作用提供了证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/0c6d2c0cdaf3/pone.0072595.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/47d384d0a468/pone.0072595.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/5d4d6b1237e8/pone.0072595.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/8bb1c3d09b25/pone.0072595.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/55f3eaf1c25e/pone.0072595.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/207eead1ce63/pone.0072595.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/eb7b4a37fcbf/pone.0072595.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/96991165b596/pone.0072595.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/fdd45f1eea5e/pone.0072595.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/0c6d2c0cdaf3/pone.0072595.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/47d384d0a468/pone.0072595.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/5d4d6b1237e8/pone.0072595.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/8bb1c3d09b25/pone.0072595.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/55f3eaf1c25e/pone.0072595.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/207eead1ce63/pone.0072595.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/eb7b4a37fcbf/pone.0072595.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/96991165b596/pone.0072595.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/fdd45f1eea5e/pone.0072595.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0175/3737131/0c6d2c0cdaf3/pone.0072595.g009.jpg

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