Munch-Andersen Thor, Sorensen Kaspar, Aachmann-Andersen Niels-Jacob, Aksglaede Lise, Juul Anders, Helge Jørn W
Department of Biomedical Sciences, Center for Healthy Aging, University of Copenhagen, Denmark.
Int J Circumpolar Health. 2013 Aug 7;72. doi: 10.3402/ijch.v72i0.21458. Print 2013.
In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children.
In total, 187 Inuit and 132 Danish children (5.7-17.1 years) had examinations of anthropometrics, body fat content, pubertal staging, fasting blood and aerobic fitness.
Plasma leptin was higher in Danish boys [3,774 (4,741-3,005)] [pg/mL unadjusted geometric mean (95% CI)] compared to both northern [2,076 (2,525-1,706)] (p < 0.001) and southern (2,515 (3,137-2,016)) (p < 0.001) living Inuit boys and higher in Danish girls [6,988 (8,353-5,847)] compared to southern living Inuit girls [4,910 (6,370-3,785)] (p = 0.021) and tended to be higher compared to northern living Inuit girls [5,131 (6,444-4,085)] (p = 0.052). Plasma adiponectin was higher for both Danish boys [22,359 (2,573-19,428)] [ng/mL unadjusted geometric mean (95% CI)] and girls [26,609 (28,994-24,420)] compared to southern living Inuit boys [15,306 (18,406-12,728)] and girls [18,864 (22,640-15,717)] (both p < 0.001), respectively. All differences remained after adjustment for body fat percentage (BF%), aerobic fitness, age and puberty. The leptin/adiponectin ratio was higher in Danish boys and tended to be higher in Danish girls compared to northern living Inuit boys and girls, respectively. These differences were eliminated after adjustment for BF%, aerobic fitness, age and puberty.
In contrast to our hypothesis, plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children. As expected, plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile.
在最近的一项研究中，我们发现格陵兰因纽特儿童的代谢状况比丹麦儿童更差。有氧适能和肥胖只能部分解释这些差异。因此，我们着手评估和比较丹麦和因纽特儿童的血浆瘦素和脂联素水平。
总共187名因纽特儿童和132名丹麦儿童（5.7 - 17.1岁）接受了人体测量、体脂含量、青春期分期、空腹血液和有氧适能检查。
丹麦男孩的血浆瘦素水平[3,774（4,741 - 3,005）][pg/mL未调整几何均值（95%CI）]高于居住在北方的因纽特男孩[2,076（2,525 - 1,706）]（p < 0.001）和居住在南方的因纽特男孩[2,515（3,137 - 2,016）]（p < 0.001）；丹麦女孩的血浆瘦素水平[6,988（8,353 - 5,847）]高于居住在南方的因纽特女孩[4,910（6,370 - 3,785）]（p = 0.021），与居住在北方的因纽特女孩[5,131（6,444 - 4,085）]相比也有升高趋势（p = 0.052）。丹麦男孩[22,359（2,573 - 19,428）][ng/mL未调整几何均值（95%CI）]和女孩[26,609（28,994 - 24,420）]的血浆脂联素水平均高于居住在南方的因纽特男孩[15,306（18,406 - 12,728）]和女孩[18,864（22,640 - 15,717）]（p均< 0.001）。在对体脂百分比（BF%）、有氧适能、年龄和青春期进行调整后，所有差异依然存在。与居住在北方的因纽特男孩和女孩相比，丹麦男孩的瘦素/脂联素比值更高，丹麦女孩也有升高趋势。在对BF%、有氧适能、年龄和青春期进行调整后，这些差异消失。
与我们的假设相反，尽管丹麦儿童的代谢状况比因纽特儿童更健康，但其血浆瘦素水平更高。正如预期的那样，代谢状况最差的因纽特儿童血浆脂联素水平最低。
