Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Obesity (Silver Spring). 2013 Jun;21(6):1226-31. doi: 10.1002/oby.20203. Epub 2013 May 13.
During recent decades, the prevalence of metabolic morbidity has increased rapidly in adult Greenlandic Inuit. To what extent this is also reflected in the juvenile Inuit population is unknown. The objective was, therefore, in the comparison with Danish children, to evaluate metabolic profiles in Greenlandic Inuit children from the capital in the southern and from the northern most villages
187 Inuit and 132 Danish children were examined with anthropometrics, pubertal staging, fasting blood samples, and a maximal aerobic test.
Both Inuit children living in Nuuk and the northern villages had significantly higher glucose, total cholesterol, apolipoprotein A1 levels, and diastolic blood pressure compared with Danish children after adjustment for differences in adiposity and aerobic fitness levels. The Inuit children living in Nuuk had significantly higher BMI, body fat %, HbA1 c, and significantly lower aerobic fitness and ApoA1 levels than northern living Inuit children.
Greenlandic Inuit children had adverse metabolic health profile compared to the Danish children, the differences where more pronounced in Inuit children living in Nuuk. The tendencies toward higher prevalence of diabetes and metabolic morbidity in the adult Greenlandic Inuit population may also be present in the Inuit children population.
近几十年来，格陵兰因纽特成年人的代谢性疾病患病率迅速上升。这种情况在青少年因纽特人群中反映到什么程度尚不清楚。因此，本研究的目的是与丹麦儿童相比，评估格陵兰南部首府和最北部村庄的因纽特儿童的代谢特征。
对 187 名因纽特儿童和 132 名丹麦儿童进行了人体测量学、青春期分期、空腹血样和最大有氧测试。
调整了肥胖和有氧健身水平的差异后，与丹麦儿童相比，居住在努克和北部村庄的因纽特儿童的血糖、总胆固醇、载脂蛋白 A1 水平和舒张压均显著升高。与北部因纽特儿童相比，居住在努克的因纽特儿童的 BMI、体脂%、HbA1c 更高，而有氧健身和 ApoA1 水平则更低。
与丹麦儿童相比，格陵兰因纽特儿童的代谢健康状况较差，居住在努克的因纽特儿童的差异更为明显。成年格陵兰因纽特人群中糖尿病和代谢性疾病患病率上升的趋势也可能存在于因纽特儿童人群中。
