Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Epilepsia. 2013 Sep;54(9):e142-5. doi: 10.1111/epi.12337. Epub 2013 Aug 14.
Interleukin 17A (IL-17A) is implicated in the pathogenesis of several neuroimmunologic diseases. We aimed to evaluate the relationship between IL-17A and seizure severity in patients with epilepsy. Seventy patients with probable symptomatic epilepsy and 68 healthy controls were included. Interictal serum IL-17A and related cytokine (IL-23, IL-6, IL-1β, interferon gamma (IFN-γ), and IL-10) levels were measured. The relationship between seizure severity and cytokine concentrations was assessed by Spearman correlation and multivariate linear regression test. IL-17A levels in the cerebrospinal fluid (CSF) were tested in 30 additional patients with epilepsy, either in the postictal or interictal period and 15 patients with idiopathic inflammatory demyelinating diseases (IIDDs). Interictal serum IL-17A levels were significantly elevated in patients with epilepsy compared to controls. IL-6, IFN-γ, and IL-1β levels were also markedly elevated. Spearman correlation analysis revealed positive correlation between IL-17A, IL-6 levels and Veterans Administration Seizures Frequency and Severity Rating Scale score(VA score); IFN-γ, IL-10 levels, and National Hospital Seizure Severity Scale (NHS3) score. In addition, IL-17A levels correlated significantly with seizure frequency. Multivariate linear regression test showed that only IL-17A levels were independently positively correlated with VA scores (B = 0.288, p = 0.027). Postictal IL-17A levels in the CSF were significantly elevated compared to interictal patients and patients with IIDDs. Our results suggest that interictal IL-17A levels correlated highly with seizure severity.
白细胞介素 17A (IL-17A) 参与了几种神经免疫疾病的发病机制。我们旨在评估 IL-17A 与癫痫患者癫痫发作严重程度之间的关系。纳入 70 例可能为症状性癫痫患者和 68 例健康对照者。检测了发作间期血清 IL-17A 和相关细胞因子（IL-23、IL-6、IL-1β、干扰素γ (IFN-γ) 和 IL-10）水平。采用 Spearman 相关和多元线性回归检验评估癫痫发作严重程度与细胞因子浓度之间的关系。另外还在 30 例癫痫患者发作后或发作间期及 15 例特发性炎症性脱髓鞘疾病（IIDDs）患者中检测了脑脊液（CSF）中 IL-17A 水平。与对照组相比，癫痫患者发作间期血清 IL-17A 水平明显升高，IL-6、IFN-γ 和 IL-1β 水平也明显升高。Spearman 相关分析显示，IL-17A、IL-6 水平与退伍军人管理局癫痫发作频率和严重程度评分（VA 评分）呈正相关；IFN-γ、IL-10 水平与国家医院癫痫严重程度评分（NHS3 评分）呈正相关。此外，IL-17A 水平与癫痫发作频率显著相关。多元线性回归检验显示，只有 IL-17A 水平与 VA 评分呈独立正相关（B = 0.288，p = 0.027）。与发作间期患者和 IIDDs 患者相比，CSF 中的发作后 IL-17A 水平显著升高。我们的结果表明，发作间期 IL-17A 水平与癫痫发作严重程度高度相关。
