Bhogaraju Sagar, Engel Benjamin D, Lorentzen Esben
Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, Martinsried, D-82152, Germany.
Cilia. 2013 Aug 14;2(1):10. doi: 10.1186/2046-2530-2-10.
Intraflagellar transport (IFT) is required for the assembly and maintenance of cilia, as well as the proper function of ciliary motility and signaling. IFT is powered by molecular motors that move along the axonemal microtubules, carrying large complexes of IFT proteins that travel together as so-called trains. IFT complexes likely function as adaptors that mediate interactions between anterograde/retrograde motors and ciliary cargoes, facilitating cargo transport between the base and tip of the cilium. Here, we provide an up-to-date review of IFT complex structure and architecture, and discuss how interactions with cargoes and motors may be achieved.
鞭毛内运输（IFT）对于纤毛的组装和维持以及纤毛运动和信号传导的正常功能是必需的。IFT由沿着轴丝微管移动的分子马达提供动力，携带称为列车的IFT蛋白大复合物一起移动。IFT复合物可能作为衔接子，介导顺行/逆行马达与纤毛货物之间的相互作用，促进货物在纤毛基部和顶端之间的运输。在这里，我们提供了关于IFT复合物结构和架构的最新综述，并讨论了如何实现与货物和马达的相互作用。
