Masaryk Memorial Cancer Institute, Regional Centre for Applied Molecular Oncology, Zluty kopec 7, 65653 Brno, Czech Republic.
Mol Cancer. 2013 Aug 14;12(1):93. doi: 10.1186/1476-4598-12-93.
Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epigenetic mechanisms. Moreover, in the growing tumor, cells are exposed to insufficient nutrient supply, low oxygen availability (hypoxia) and/or reactive oxygen species. These physiological stresses force them to switch into more adaptable and aggressive phenotypes. This paper summarizes the role of two key mediators of cellular stress responses, namely p53 and HIF, which significantly affect cancer progression and compromise treatment outcomes. Furthermore, it describes cross-talk between these factors.
异常的生长速度、转移潜能以及对导致细胞凋亡的信号的不敏感性是通过遗传或表观遗传机制发展的肿瘤的广泛研究特征。此外，在不断生长的肿瘤中，细胞会受到营养供应不足、缺氧（低氧）和/或活性氧的影响。这些生理压力迫使它们转变为更具适应性和侵袭性的表型。本文总结了细胞应激反应的两个关键介质 p53 和 HIF 的作用，它们显著影响癌症的进展并影响治疗效果。此外，还描述了这些因素之间的相互作用。
