• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

从余甘子中分离得到的三种新的紫檀烷酮及其抗 TMV 活性。

Three novel xanthones from Garcinia paucinervis and their anti-TMV activity.

机构信息

Yunnan Academy of Tobacco Agricultural Sciences, Yuxi 653100, China.

出版信息

Molecules. 2013 Aug 13;18(8):9663-9. doi: 10.3390/molecules18089663.

DOI:10.3390/molecules18089663
PMID:23945641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269950/
Abstract

Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1-3 and five known analogues 4-8. Structural elucidations of 1-3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1-3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC₅₀ value of 21.4 µM.

摘要

从余甘子的叶子中进行的植物化学研究导致分离出三种新的紫檀烷 1-3 和五种已知类似物 4-8。通过光谱方法,如 1D 和 2D(HMQC、HMBC 和 ROESY)NMR 光谱学,以及高分辨率质谱法,对 1-3 的结构进行了阐明。化合物 1-3 表现出抗 TMV 活性,抑制率超过 20%,特别是化合物 1,其 IC₅₀ 值更低,为 21.4 µM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e3/6269950/fd9d24440be3/molecules-18-09663-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e3/6269950/2fc0ae19dbd2/molecules-18-09663-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e3/6269950/fd9d24440be3/molecules-18-09663-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e3/6269950/2fc0ae19dbd2/molecules-18-09663-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e3/6269950/fd9d24440be3/molecules-18-09663-g002.jpg

相似文献

1
Three novel xanthones from Garcinia paucinervis and their anti-TMV activity.从余甘子中分离得到的三种新的紫檀烷酮及其抗 TMV 活性。
Molecules. 2013 Aug 13;18(8):9663-9. doi: 10.3390/molecules18089663.
2
Three new biphenyls from the twigs of Garcinia tetralata and their anti-tobacco mosaic virus activity.来自多花山竹子嫩枝的三种新联苯及其抗烟草花叶病毒活性。
J Asian Nat Prod Res. 2016 Dec;18(12):1115-1121. doi: 10.1080/10286020.2016.1193490. Epub 2016 Jun 17.
3
Xanthones from the herb of Swertia elata and their anti-TMV activity.来自高獐牙菜全草的呫吨酮及其抗烟草花叶病毒活性。
Nat Prod Res. 2016 Aug;30(16):1810-5. doi: 10.1080/14786419.2015.1081198. Epub 2015 Sep 2.
4
[A new flavone from stems of Garcinia bracteata and its anti-TMV activity].
Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(21):4205-7.
5
Two new biphenyls from the stems of Garcinia tetralata.从四角藤茎中分离得到的两种新联苯。
Nat Prod Res. 2017 Jul;31(13):1544-1550. doi: 10.1080/14786419.2017.1283492. Epub 2017 Feb 5.
6
Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells.来自少花藤黄的具有体外抗HL-60细胞增殖活性的呫吨酮类化合物。
Arch Pharm Res. 2016 Feb;39(2):172-177. doi: 10.1007/s12272-015-0692-6. Epub 2015 Dec 10.
7
Structure elucidation and NMR spectral assignment of five new xanthones from the bark of Garcinia xanthochymus.来自山竹树皮的五种新呫吨酮的结构解析及核磁共振光谱归属
Magn Reson Chem. 2008 Dec;46(12):1180-4. doi: 10.1002/mrc.2317.
8
Antibacterial caged-tetraprenylated xanthones from the fruits of Garcinia hanburyi.来自藤黄果的具有抗菌活性的笼状四异戊烯基氧杂蒽酮类化合物。
Chem Pharm Bull (Tokyo). 2005 Jul;53(7):850-2. doi: 10.1248/cpb.53.850.
9
Three new xanthones from the resin of Garcinia hanburyi.从藤黄科植物汉氏胡颓子树脂中分离得到的 3 个新的紫檀烷酮。
Planta Med. 2013 Jun;79(9):792-6. doi: 10.1055/s-0032-1328537. Epub 2013 May 13.
10
Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv.多花山竹子(Garcinia polyantha Oliv.)树干中的三种呫吨酮类化合物:多花山竹子呫吨酮A、B和C
Phytochemistry. 2008 Feb;69(4):1013-7. doi: 10.1016/j.phytochem.2007.10.002. Epub 2007 Nov 26.

引用本文的文献

1
In silico exploration of natural xanthone derivatives as potential inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and cellular entry.天然氧杂蒽酮衍生物作为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)复制和细胞进入潜在抑制剂的计算机模拟研究
J Comput Aided Mol Des. 2025 Feb 17;39(1):7. doi: 10.1007/s10822-025-00585-5.
2
New depsidone and dichromone from the stems of Garcinia paucinervis with antiproliferative activity.具有抗增殖活性的余甘子茎中新的去甲二氢愈创木酸和二氢克酮酸。
J Nat Med. 2019 Jan;73(1):278-282. doi: 10.1007/s11418-018-1247-1. Epub 2018 Sep 4.
3
Chemical and Biological Research on Herbal Medicines Rich in Xanthones.

本文引用的文献

1
Identification and evaluation of apoptotic compounds from Garcinia paucinervis.从余甘子中鉴定和评价凋亡化合物。
Bioorg Med Chem. 2010 Jul 15;18(14):4957-64. doi: 10.1016/j.bmc.2010.06.014. Epub 2010 Jun 10.
2
Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr.从鸦胆子中提取的抗烟草花叶病毒(TMV)奎宁类生物碱
J Agric Food Chem. 2010 Feb 10;58(3):1572-7. doi: 10.1021/jf903434h.
3
Structures of three new isoprenylated xanthones, cudraxanthones e, f, and g 1,2.三种新的异戊烯基黄烷酮,cudraxanthones e、f 和 g 1,2 的结构。
草药中富含黄烷酮的化学和生物学研究
Molecules. 2017 Oct 11;22(10):1698. doi: 10.3390/molecules22101698.
4
A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervis and their biological activities.少花藤黄树叶中的一种新双黄酮和一种新三萜及其生物活性。
J Nat Med. 2017 Oct;71(4):642-649. doi: 10.1007/s11418-017-1092-7. Epub 2017 May 26.
5
Synthesis and Antiviral Activity of Novel 1,4-Pentadien-3-one Derivatives Containing a 1,3,4-Thiadiazole Moiety.含1,3,4-噻二唑部分的新型1,4-戊二烯-3-酮衍生物的合成及其抗病毒活性
Molecules. 2017 Apr 21;22(4):658. doi: 10.3390/molecules22040658.
Planta Med. 1990 Aug;56(4):399-402. doi: 10.1055/s-2006-960993.
4
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).山竹果皮中的抗氧化剂氧杂蒽酮。
J Agric Food Chem. 2006 Mar 22;54(6):2077-82. doi: 10.1021/jf052649z.
5
Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi.来自藤黄树脂的细胞毒性多异戊烯基呫吨酮
Chem Pharm Bull (Tokyo). 2006 Feb;54(2):265-7. doi: 10.1248/cpb.54.265.
6
Synthesis and antiviral activity of novel chiral cyanoacrylate derivatives.新型手性氰基丙烯酸酯衍生物的合成与抗病毒活性
J Agric Food Chem. 2005 Oct 5;53(20):7886-91. doi: 10.1021/jf051050w.
7
Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics.α-山竹素对耐万古霉素肠球菌(VRE)的抗菌活性及与抗生素的协同作用。
Phytomedicine. 2005 Mar;12(3):203-8. doi: 10.1016/j.phymed.2003.09.012.
8
gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.γ-山竹素抑制IκB激酶活性并降低脂多糖诱导的C6大鼠胶质瘤细胞中环氧合酶-2基因的表达。
Mol Pharmacol. 2004 Sep;66(3):667-74. doi: 10.1124/mol.104.002626.
9
Antibacterial xanthones from the leaves of Garcinia nigrolineata.来自黑纹藤黄树叶的抗菌氧杂蒽酮类化合物。
J Nat Prod. 2003 Dec;66(12):1531-5. doi: 10.1021/np0303254.
10
Xanthones from the bark of Garcinia merguensis.
Phytochemistry. 2003 Jun;63(4):467-70. doi: 10.1016/s0031-9422(02)00433-8.