Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, SE-171 82 Solna, Sweden.
Parasitology. 2013 Dec;140(14):1735-40. doi: 10.1017/S003118201300084X. Epub 2013 Aug 15.
Most human cases of cryptosporidiosis are caused by Cryptosporidium parvum or Cryptosporidium hominis, but the use of molecular diagnostic methods has revealed that several other less common species or genotypes can also be involved. Here, we describe two unusual causes of cryptosporidiosis, one being the recently described species Cryptosporidium viatorum and the other Cryptosporidium chipmunk genotype I. Two Swedish patients who were infected with C. viatorum had travelled to Kenya and Guatemala, respectively, and two others had been infected with Cryptosporidium chipmunk genotype I in Sweden. None of these four patients were immunocompromised, and all four showed classical symptoms of cryptosporidiosis. We performed extensive molecular characterization, including analysis of four loci. The two C. viatorum isolates were found to differ slightly at the 70-kDa heat shock protein locus, which may indicate a local geographical variation in this species that has previously been described exclusively on the Indian subcontinent.
大多数人类隐孢子虫病是由微小隐孢子虫或人隐孢子虫引起的，但分子诊断方法的应用表明，其他几种不太常见的种或基因型也可能涉及其中。在这里，我们描述了两种隐孢子虫病的不常见病因，一种是最近描述的种——维氏隐孢子虫，另一种是地松鼠基因型 I。两名感染 C.viatorum 的瑞典患者分别前往肯尼亚和危地马拉，另有两名患者在瑞典感染了地松鼠基因型 I。这四名患者均无免疫功能低下，且均表现出典型的隐孢子虫病症状。我们进行了广泛的分子特征分析，包括对四个基因座的分析。两个 C.viatorum 分离株在 70 kDa 热休克蛋白基因座上略有差异，这可能表明该物种在当地存在地理变异，此前该物种仅在印度次大陆被描述过。
