College of Animal Science and Technology , Henan University of Science and Technology , Luoyang , PR China.
Syst Biol Reprod Med. 2013 Dec;59(6):312-8. doi: 10.3109/19396368.2013.826296. Epub 2013 Aug 16.
A sub-acute toxicity test was performed to investigate the effects of molybdenum (Mo) on ovarian function. ICR adult female mice were exposed to Mo by free access to distilled water containing the Mo at 5, 10, 20, and 40 mg/L for 14 days. Compared to the control group, M II oocyte morphology, ovary index, and ovulation improved within the 5 mg/L Mo group, but were negatively affected by Mo at 40 mg/L. Morphologically abnormal ovarian mitochondria were observed at ≥ 20 mg/L. These alterations accompanied the changes in superoxide dismutase (SOD), glutathione peroxidise (GPx), and malondialdehyde (MDA) levels in ovaries. In conclusion, Mo affects oocyte quality possibly through regulating ovarian oxidative stress in a dose-dependent manner. It appears that Mo may improve ovarian function at a suitable concentration, which might be a candidate for the treatment of female infertility.
进行了一项亚急性毒性试验，以研究钼（Mo）对卵巢功能的影响。ICR 成年雌性小鼠通过自由接触含有 5、10、20 和 40mg/L Mo 的蒸馏水 14 天来暴露于 Mo 中。与对照组相比，5mg/L Mo 组的 M II 卵母细胞形态、卵巢指数和排卵有所改善，但 40mg/L Mo 组则受到负面影响。在≥20mg/L 时观察到形态异常的卵巢线粒体。这些改变伴随着卵巢中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和丙二醛（MDA）水平的变化。总之，Mo 可能通过调节卵巢氧化应激以剂量依赖的方式影响卵母细胞质量。似乎在适当的浓度下 Mo 可以改善卵巢功能，这可能是治疗女性不孕的候选药物。
