Institute of Human Genetics, Polish Academy of Sciences, Department of Environmental Mutagenesis, 60-479 Poznań, Poland.
Crit Rev Oncol Hematol. 2013 Dec;88(3):716-28. doi: 10.1016/j.critrevonc.2013.07.012. Epub 2013 Aug 12.
The results of treatment of head and neck tumors remain poor for decades. It means that after surgery, chemotherapy is not a proper choice, as tumors of this region are relatively resistant to cytotoxic drugs. A little progress was noted only for radiotherapy outcome. Consequently, clinicians and researchers' expectations are focused on targeted therapy, where microRNAs (miRNAs, miRs) seem to be the most promising target. After the year 2000, miRNAs became new players on the scene of cancer science. Since then, extensive investigations have been performed with a hope of finding a new prognostic and diagnostic tool and bridging them with a bright new way of understanding the basis of molecular carcinogenesis. miRNAs display astonishing specificity and thus are associated with pathoclinical parameters of the disease. After more than a decade of ongoing studies, in this review we attempt to summarize the current knowledge of miRNAs in malignancies arising in head and neck sites and with a majority of squamous cells of the epithelium.
几十年来，头颈部肿瘤的治疗效果仍然不佳。这意味着手术后，化疗并不是一个合适的选择，因为该区域的肿瘤对细胞毒药物相对具有抗性。只有放疗结果有一些进展。因此，临床医生和研究人员的期望集中在靶向治疗上，而 microRNAs（miRNAs，miRs）似乎是最有前途的靶点。2000 年后，miRNAs 成为癌症科学领域的新成员。从那时起，人们进行了广泛的研究，希望找到一种新的预后和诊断工具，并将其与理解分子致癌基础的新途径联系起来。miRNAs 表现出惊人的特异性，因此与疾病的病理临床参数相关。经过十多年的持续研究，在这篇综述中，我们试图总结目前对头颈部和上皮鳞状细胞恶性肿瘤中 miRNAs 的认识。
