Department of Hematology, Aarhus University Hospital, Tage Hansensgade 2, 8000, Aarhus C., Denmark,
J Cancer Surviv. 2013 Dec;7(4):614-23. doi: 10.1007/s11764-013-0300-z. Epub 2013 Aug 15.
The aims of this study were to determine the proportion of return to work (RTW) among sick-listed patients diagnosed with one of eight subtypes of hematological malignancies; to evaluate the influence of type of hematological malignancy, comorbidity, use of anxiolytics and antidepressants, socioeconomic and demographic factors on RTW; and to investigate if these associations differ between genders.
We combined data from national registers on all Danish patients diagnosed with hematological malignancies between 2000 and 2007. A total of 1,741 patients on long-term sick leave were followed until RTW, emigration, permanent withdrawal from the labor market, death, or February 2012, whichever came first.
A total of 1,140 (65 %) patients returned to work. A strong association was found between type of diagnosis and RTW (p < 0.001), and the proportion of RTW was lowest for patients with multiple myeloma or acute leukemia compared to patients with Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, chronic myeloid leukemia, and chronic lymphoid leukemia. Use of antidepressants or anxiolytics after diagnosis, gender, age, and educational level were also associated with RTW. Surprisingly, comorbidity was not associated with RTW (p = 0.94); gender only modified the association between age and RTW.
Two thirds of patients with hematological malignancies on sick leave RTW. A number of factors seem to lead to a poor prognosis, the hematological diagnosis being the most important, and these should be taken into account when performing studies on work outcome for patients with hematological malignancies.
Knowledge in this area should assist in identification of hematological cancer patients at risk of not returning to work so that early targeted rehabilitation interventions can be initiated.
本研究旨在确定诊断为八种血液恶性肿瘤亚型之一的请病假患者中重返工作岗位（RTW）的比例；评估血液恶性肿瘤类型、合并症、使用抗焦虑药和抗抑郁药、社会经济和人口统计学因素对 RTW 的影响；并调查这些关联是否因性别而异。
我们将丹麦所有 2000 年至 2007 年间诊断为血液恶性肿瘤的患者的国家登记数据进行了合并。共有 1741 名长期请病假的患者接受了随访，直至 RTW、移民、永久退出劳动力市场、死亡或 2012 年 2 月（以先发生者为准）。
共有 1140 名（65%）患者重返工作岗位。诊断类型与 RTW 之间存在很强的关联（p<0.001），与霍奇金淋巴瘤、弥漫性大 B 细胞淋巴瘤、滤泡性淋巴瘤、慢性髓性白血病和慢性淋巴细胞白血病患者相比，多发性骨髓瘤或急性白血病患者的 RTW 比例最低。诊断后使用抗抑郁药或抗焦虑药、性别、年龄和教育水平也与 RTW 相关。令人惊讶的是，合并症与 RTW 无关（p=0.94）；性别仅改变了年龄与 RTW 之间的关联。
三分之二请病假的血液恶性肿瘤患者 RTW。许多因素似乎导致预后不良，血液学诊断是最重要的，在对血液恶性肿瘤患者的工作结果进行研究时应考虑这些因素。
该领域的知识应该有助于识别有不能重返工作岗位风险的血液癌患者，以便及早开始有针对性的康复干预措施。
