Department of Pediatrics, Dunedin School of Medicine, Otago University, New Zealand.
J Am Soc Nephrol. 2013 Sep;24(9):1347-56. doi: 10.1681/ASN.2012121199. Epub 2013 Aug 15.
The ability to reprogram fully differentiated cells into a pluripotent embryonic state, termed induced pluripotent stem cells (iPSCs), has been met with great excitement. iPSC technology has advanced the fundamental study of disease modeling with the potential for cell-replacement therapy, especially in the neuronal and cardiac fields. However, renal medicine as of yet has not benefited from similar advancements. This review summarizes the unique characteristics of iPSCs and their potential applications for modeling kidney disease. Pioneering such endeavors could yield constructs that recapitulate disease phenotypes, open avenues for more targeted drug development, and potentially serve as replenishable sources for replacement of kidney cells in the setting of human disease.
将完全分化的细胞重编程为多能胚胎状态的能力，称为诱导多能干细胞（iPSC），引起了极大的兴奋。iPSC 技术推进了疾病建模的基础研究，具有细胞替代治疗的潜力，特别是在神经元和心脏领域。然而，肾脏医学尚未从中受益于类似的进展。本综述总结了 iPSC 的独特特征及其在肾脏疾病建模中的潜在应用。开展此类研究可能会产生能够重现疾病表型的构建体，为更有针对性的药物开发开辟途径，并可能成为人类疾病中肾脏细胞替代的可再生来源。
