Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida 201307, Uttar Pradesh, India.
Environ Toxicol Pharmacol. 2013 Nov;36(3):807-12. doi: 10.1016/j.etap.2013.07.005. Epub 2013 Jul 20.
Nanotechnology, with its advent, has made deep inroads into therapeutics. It has revolutionized conventional approaches in drug designing and delivery systems by creating a large array of nanoparticles that can pass even through relatively impermeable membranes such as blood brain barrier. Like the two sides of a coin, nanotechnology too has its own share of disadvantages which in this scenario is the toxicology of these nanoparticles. Numerous studies have discussed the toxicity of various nanoparticles and the recent advancements done in the field of nanotechnology is to make it less toxic. "Green synthesis" of nanoparticles is one such approach. The review summarizes the toxicity associated with the nanoparticles and the advancement of "green" nanomaterials to resolve the toxicity issues.
纳米技术的出现已经深入到治疗学领域。它通过创造出大量的纳米粒子，颠覆了传统的药物设计和输送系统方法，这些纳米粒子甚至可以穿过相对不渗透的细胞膜，如血脑屏障。就像硬币的两面一样，纳米技术也有其自身的缺点，在这种情况下，就是这些纳米粒子的毒理学。许多研究都讨论了各种纳米粒子的毒性，而纳米技术领域的最新进展就是使它们的毒性降低。“绿色合成”纳米粒子就是这样一种方法。这篇综述总结了与纳米粒子相关的毒性，以及“绿色”纳米材料的进步，以解决毒性问题。
