Stockinger Z, Geary N
Psychology Department, Columbia University, New York, NY 10027.
Physiol Behav. 1990 Jun;47(6):1283-5. doi: 10.1016/0031-9384(90)90384-g.
Rats maintained on a LF diet (Purina chow) were pretreated with 0.3 M/kg 2-mercaptoacetate, an antagonist of B-oxidation of fatty acids, 60 min before sham feeding condensed milk with open gastric cannulas. 2-Mercaptoacetate significantly increased 30-min milk intake by about 35%. This suggests that blockade of fatty acid oxidation 1) participates control of feeding even in rats adapted to low fat diets, and 2) modulates not only the timing of meal initiation as previously reported by others, but also may influence the rate of ingestion and/or meal size. Finally, 2-mercaptoacetate pretreatment did not block the synergistic inhibition of sham feeding elicited by simultaneous injections of glucagon and cholecystokinin.
给食用低脂饮食（普瑞纳大鼠饲料）的大鼠，在通过开放胃插管假饲炼乳前60分钟，用0.3M/kg的2-巯基乙酸盐（一种脂肪酸β氧化的拮抗剂）进行预处理。2-巯基乙酸盐使30分钟的乳汁摄入量显著增加了约35%。这表明脂肪酸氧化的阻断1）即使在适应低脂饮食的大鼠中也参与进食控制，并且2）不仅如其他人先前报道的那样调节进食开始的时间，还可能影响摄入速率和/或进食量。最后，2-巯基乙酸盐预处理并未阻断由同时注射胰高血糖素和胆囊收缩素引起的对假饲的协同抑制作用。
