Langhans W, Scharrer E
Behav Neural Biol. 1987 Jan;47(1):7-16. doi: 10.1016/s0163-1047(87)90112-9.
To characterize the role of fatty acid oxidation in the control of food intake, we investigated the effect of 2-mercaptoacetate, which inhibits fatty acid oxidation, on meal patterns and cumulative food intake in rats. Rats were fed either a medium fat (MF, 18% fat) or a low fat (LF, 3.3% fat) diet. Mercaptoacetate (400 mumole/kg body wt), intraperitoneally injected in the middle of the bright or at the onset of the dark phase of the diurnal lighting cycle, increased cumulative food intake in MF rats by shortening the latency to eat after injection and the duration of the subsequent intermeal interval (IMI) without affecting the size of the first meal. Mercaptoacetate, injected in the middle of the bright phase, reduced the latency to eat but did not affect the duration of the subsequent IMI or cumulative food intake in LF rats. A higher dose of mercaptoacetate (600 mumole/kg body wt), initially increased and later decreased cumulative food intake in MF rats. The initial increase in food intake was due to shorter IMIs; the subsequent decrease in food intake was due to smaller meals after mercaptoacetate injection than after control injection. The results indicate that a drop in fatty acid oxidation caused by mercaptoacetate triggers a meal. This implicates fatty acid oxidation in the maintenance of postprandial satiety.
为了描述脂肪酸氧化在食物摄入控制中的作用，我们研究了抑制脂肪酸氧化的2-巯基乙酸对大鼠进食模式和累积食物摄入量的影响。给大鼠喂食中等脂肪（MF，18%脂肪）或低脂肪（LF，3.3%脂肪）饮食。在昼夜光照周期的明期中间或暗期开始时腹腔注射2-巯基乙酸（400微摩尔/千克体重），通过缩短注射后进食潜伏期和随后的餐间间隔（IMI）持续时间，增加了MF大鼠的累积食物摄入量，而不影响第一餐的食量。在明期中间注射2-巯基乙酸，缩短了LF大鼠的进食潜伏期，但不影响随后的IMI持续时间或累积食物摄入量。更高剂量的2-巯基乙酸（600微摩尔/千克体重）最初增加了MF大鼠的累积食物摄入量，随后又使其减少。最初食物摄入量的增加是由于IMI缩短；随后食物摄入量的减少是由于注射2-巯基乙酸后每餐食量小于注射对照物后。结果表明，2-巯基乙酸引起的脂肪酸氧化下降引发了进食。这意味着脂肪酸氧化在餐后饱腹感的维持中起作用。
