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参与构建、维持和重塑酵母细胞壁的蛋白质。

Proteins involved in building, maintaining and remodeling of yeast cell walls.

出版信息

Curr Genet. 2013 Nov;59(4):171-85. doi: 10.1007/s00294-013-0403-0.

Abstract

The cell wall defines the shape and provides osmotic stability to the yeast cell. It also serves to anchor proteins required for communication of the yeast cell with surrounding molecules and other cells. It is synthesized as a complex structure with β-1,3-glucan chains forming the basic network to which β-1,6-glucan, chitin and a number of mannoproteins are attached. Synthesis, maintaining and remodeling of this complex structure require a set of different synthases, hydrolases and transglycosidases whose concerted activities provide necessary firmness but at the same time flexibility of the wall moiety. The present state of comprehension of the interplay of these proteins in the yeast cell wall is the subject of this article.

摘要

细胞壁为酵母细胞提供形状和渗透稳定性。它还用于固定与酵母细胞与周围分子和其他细胞进行通讯所需的蛋白质。它作为一种复杂结构合成,β-1,3-葡聚糖链形成基本网络,β-1,6-葡聚糖、几丁质和许多甘露糖蛋白附着在该网络上。这种复杂结构的合成、维持和重塑需要一组不同的合成酶、水解酶和转糖苷酶,它们的协同作用提供了必要的坚固性,但同时也使细胞壁部分具有灵活性。本文讨论了目前对这些蛋白质在酵母细胞壁中的相互作用的理解。

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