铁线蕨的植物化学和生物学研究
Phytochemical and biological studies of Adiantum capillus-veneris L.
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
出版信息
Saudi Pharm J. 2011 Apr;19(2):65-74. doi: 10.1016/j.jsps.2011.01.007. Epub 2011 Jan 18.
Abstract
Chromatographic fractionation of the alcoholic extract of the dried fronds of Adiantum capillus-veneris L. (Adiantaceae) yielded seven compounds: four triterpenoidal compounds belonging to adiantane and filicane groups were isolated from the hexane fraction and identified as isoadiantone (1); isoadiantol-B (2); 3-methoxy-4-hydroxyfilicane (3) and 3,4-dihydroxyfilicane (4) and three flavonoids were isolated from the ethyl acetate fraction and identified as: quercetin (5), quercetin-3-O-glucoside (6) and quercetin-3-O-rutinoside (rutin) (7). The identification of the isolated compounds has been established through their physical, chemical and spectroscopic methods including IR, (1)H NMR, (13)C NMR, HSQC, HMBC, NOESY and MS. Biological studies of the total alcoholic extract, hexane fraction and some of the isolated compounds showed an anti-inflammatory activity while the hypoglycemic study of the total alcoholic extract showed a significant activity.
摘要
从凤尾蕨（凤尾蕨科）干燥叶片的醇提物中进行色谱分离，得到了七种化合物：从正己烷部分分离得到的四个三萜类化合物属于 adiantane 和 filicane 组，分别鉴定为 isoadiantone（1）；isoadiantol-B（2）；3-甲氧基-4-羟基 filicane（3）和 3,4-二羟基 filicane（4），从乙酸乙酯部分分离得到的三个黄酮类化合物分别鉴定为：槲皮素（5），槲皮素-3-O-葡萄糖苷（6）和槲皮素-3-O-芸香糖苷（芦丁）（7）。通过物理、化学和光谱方法（包括 IR、（1）H NMR、（13）C NMR、HSQC、HMBC、NOESY 和 MS）确定了分离化合物的结构。总醇提物、正己烷部分和部分分离化合物的生物学研究显示出抗炎活性，而总醇提物的降血糖研究显示出显著的活性。
相似文献
1
Phytochemical and biological studies of Adiantum capillus-veneris L.铁线蕨的植物化学和生物学研究
Saudi Pharm J. 2011 Apr;19(2):65-74. doi: 10.1016/j.jsps.2011.01.007. Epub 2011 Jan 18.
2
Anti-inflammatory and anti-nociceptive activities of two new triterpenoids from Adiantum capillus-veneris Linn.从凤尾蕨属植物中提取的两种新三萜类化合物的抗炎和镇痛活性。
Nat Prod Res. 2013;27(24):2304-10. doi: 10.1080/14786419.2013.828292. Epub 2013 Aug 25.
3
Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations.铁线蕨提取物的抗肥胖和降血糖作用：体内外评价
Pharm Biol. 2017 Dec;55(1):164-172. doi: 10.1080/13880209.2016.1233567. Epub 2016 Sep 23.
4
In vitro phytochemical, antibacterial, and antifungal activities of leaf, stem, and root extracts of Adiantum capillus veneris.铁线蕨叶、茎和根提取物的体外植物化学、抗菌和抗真菌活性
ScientificWorldJournal. 2014 Jan 28;2014:269793. doi: 10.1155/2014/269793. eCollection 2014.
5
Anti-inflammatory and anti-nociceptive activities of ethanolic extract and its various fractions from Adiantum capillus veneris Linn.铁线蕨中乙醇提取物及其不同馏分的抗炎和镇痛活性研究
J Ethnopharmacol. 2011 Dec 8;138(3):741-7. doi: 10.1016/j.jep.2011.10.012. Epub 2011 Oct 15.
6
Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats.双酚 A 暴露与铁线蕨植物提取物 (APE) 对双酚 A 诱导的白化大鼠生殖毒性的治疗作用。
Environ Sci Pollut Res Int. 2016 Jun;23(12):11645-57. doi: 10.1007/s11356-016-6330-0. Epub 2016 Mar 3.
7
The Effects of Adiantum capillus-veneris on Wound Healing: An Experimental In Vitro Evaluation.铁线蕨对伤口愈合的影响：一项体外实验评估
Int J Prev Med. 2014 Oct;5(10):1261-8.
8
Three new hopane-type triterpenoids from the aerial part of Adiantum capillus-veneris and their antimicrobial activities.从凤尾蕨的地上部分中分离得到的三种新的霍烷型三萜及其抗菌活性。
Fitoterapia. 2019 Mar;133:146-149. doi: 10.1016/j.fitote.2019.01.006. Epub 2019 Jan 14.
9
Fern constituents: triterpenoids from Adiantum capillus-veneris.蕨类植物成分：来自铁线蕨的三萜类化合物。
Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1273-5. doi: 10.1248/cpb.50.1273.
10
Controlling Argas arboreus and A. persicus (Acari: Argasidae) by Adiantum capillus-veneris L. extracts with phytochemical analysis.用铁角蕨提取物对硬蜱属的柏氏禽刺螨和草原革蜱进行化学分析和控制。
Vet Parasitol. 2023 Dec;324:110067. doi: 10.1016/j.vetpar.2023.110067. Epub 2023 Oct 30.
引用本文的文献
1
Anti-Inflammatory and Antimicrobial Activity of Silver Nanoparticles Green-Synthesized Using Extracts of Different Plants.使用不同植物提取物绿色合成的银纳米颗粒的抗炎和抗菌活性
Nanomaterials (Basel). 2024 Aug 25;14(17):1383. doi: 10.3390/nano14171383.
2
Mitigation of Hepatotoxicity via Boosting Antioxidants and Reducing Oxidative Stress and Inflammation in Carbendazim-Treated Rats Using L. Extract.利用 L. 提取物增强抗氧化剂、降低氧化应激和炎症来减轻苯菌灵处理大鼠的肝毒性。
Molecules. 2023 Jun 12;28(12):4720. doi: 10.3390/molecules28124720.
3
Aqueous Ethanolic Extract of Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress.福斯克氏植物的水醇提取物通过减弱α-淀粉酶和氧化应激来预防2型糖尿病。
ACS Omega. 2022 Oct 12;7(42):37724-37735. doi: 10.1021/acsomega.2c04673. eCollection 2022 Oct 25.
4
Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature.天然产物通过纳米载体的药物递送用于有效的乳腺癌治疗：文献综述。
Int J Nanomedicine. 2021 Dec 2;16:7891-7941. doi: 10.2147/IJN.S328135. eCollection 2021.
5
Ca' Granda, : Restoring an Ancient Medicinal Garden of XV-XIX Century in Milan (Italy).米兰（意大利）的 15 至 19 世纪古老药用植物园修复项目
Molecules. 2021 Nov 17;26(22):6933. doi: 10.3390/molecules26226933.
6
Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review.孟加拉国抗糖尿病植物的民族药用价值：综述
Plants (Basel). 2021 Apr 8;10(4):729. doi: 10.3390/plants10040729.
7
Anti-inflammatory effect of hydroalcoholic and aqueous extracts on acetic acid-induced colitis in rats.水醇提取物和水提取物对大鼠乙酸诱导结肠炎的抗炎作用
Avicenna J Phytomed. 2020 Sep-Oct;10(5):492-503.
8
Phytochemicals from fern species: potential for medicine applications.蕨类植物中的植物化学物质：医学应用潜力
Phytochem Rev. 2017;16(3):379-440. doi: 10.1007/s11101-016-9488-7. Epub 2017 Jan 28.
9
Healing potential of Adiantum capillus-veneris L. plant extract on bisphenol A-induced hepatic toxicity in male albino rats.铁线蕨植物提取物对双酚 A 诱导雄性白化大鼠肝毒性的修复潜力。
Environ Sci Pollut Res Int. 2018 Apr;25(12):11884-11892. doi: 10.1007/s11356-018-1211-3. Epub 2018 Feb 14.
10
Plants' Natural Products as Alternative Promising Anti- Drugs.植物天然产物作为有前景的替代抗药物。 （这段原文表述似乎不太准确规范，翻译出来的句子也有些费解，推测可能原文是“Plants' Natural Products as Alternative Promising Anti-drug Agents”之类的表述 ）
Pharmacogn Rev. 2017 Jul-Dec;11(22):104-122. doi: 10.4103/phrev.phrev_8_17.
本文引用的文献
1
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.从 Acer mandshuricum 中分离得到的三萜类化合物及其抗炎活性。
Bioorg Med Chem Lett. 2010 Mar 1;20(5):1528-31. doi: 10.1016/j.bmcl.2010.01.096. Epub 2010 Jan 25.
2
Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan.药用植物在巴基斯坦西北边境省部落社区中治疗皮肤病和民间化妆品的民族药理学应用。
J Ethnopharmacol. 2010 Mar 24;128(2):322-35. doi: 10.1016/j.jep.2010.01.052. Epub 2010 Feb 4.
3
Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata.紫菜中酚类化合物和粗提取物的抗炎特性。
J Ethnopharmacol. 2010 Mar 2;128(1):123-30. doi: 10.1016/j.jep.2009.12.037. Epub 2010 Jan 4.
4
Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo.杨梅素和槲皮素是体内环氧化酶的天然共底物。
Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):45-50. doi: 10.1016/j.plefa.2009.10.006. Epub 2009 Nov 7.
5
Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice.槲皮素微乳液对小鼠气道变应性炎症模型的抗炎作用。
Pharmacol Res. 2010 Apr;61(4):288-97. doi: 10.1016/j.phrs.2009.10.005. Epub 2009 Nov 3.
6
Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan.约旦绍巴克野生药用植物的民族药理学调查。
J Ethnopharmacol. 2009 May 4;123(1):45-50. doi: 10.1016/j.jep.2009.02.031. Epub 2009 Mar 4.
7
Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice.从楔叶铁线蕨中获得的菲烯与胆碱能、多巴胺能、谷氨酸能、γ-氨基丁酸能和速激肽能系统相互作用，从而在小鼠中发挥镇痛作用。
Pharmacol Biochem Behav. 2009 Jul;93(1):40-6. doi: 10.1016/j.pbb.2009.04.004. Epub 2009 Apr 16.
8
Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals.n-3多不饱和脂肪酸和植物甾醇对高脂血症个体的抗炎和心脏保护作用。
Atherosclerosis. 2009 Jun;204(2):476-82. doi: 10.1016/j.atherosclerosis.2008.09.020. Epub 2008 Sep 27.
9
The potential of South African plants against Mycobacterium infections.南非植物抗分枝杆菌感染的潜力。
J Ethnopharmacol. 2008 Oct 28;119(3):482-500. doi: 10.1016/j.jep.2008.08.022. Epub 2008 Aug 30.
10
Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia.来自台湾野木瓜小叶变种的抗HIV-1蛋白酶三萜类化合物。
Phytochemistry. 2008 Jun;69(9):1875-9. doi: 10.1016/j.phytochem.2008.03.004. Epub 2008 Apr 21.
Zotero 插件