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角膜缘干细胞疾病：治疗与技术进展

Limbal stem cell disease: Treatment and advances in technology.

作者信息

Chew Hall F

机构信息

Department of Ophthalmology and Vision Sciences, University of Toronto, Ontario, Canada M4N 3M5.

出版信息

Saudi J Ophthalmol. 2011 Jul;25(3):213-8. doi: 10.1016/j.sjopt.2011.04.012. Epub 2011 May 24.

DOI:10.1016/j.sjopt.2011.04.012
PMID:23960927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3729922/
Abstract

Anterior segment stem cell technology, due to its already well-defined corneal limbal stem cells with greater ease of evaluation, has been at the forefront of ophthalmic stem cell treatment and technology since 1997. This paper provides an overview of the current standard of care for treatment of limbal stem-cell deficient conditions and reviews recent treatment technologies using ex vivo expansion of cultivated limbal stem cells of the cornea.

摘要

前段干细胞技术，因其已明确的角膜缘干细胞更易于评估，自1997年以来一直处于眼科干细胞治疗和技术的前沿。本文概述了目前治疗角膜缘干细胞缺乏症的护理标准，并综述了最近使用体外扩增培养角膜缘干细胞的治疗技术。

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Limbal stem cell disease: Treatment and advances in technology.角膜缘干细胞疾病：治疗与技术进展
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Limbal stem cell transplantation: an evidence-based analysis.角膜缘干细胞移植：一项基于证据的分析。
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Ex vivo expansion of corneal limbal epithelial/stem cells for corneal surface reconstruction.用于角膜表面重建的角膜缘上皮/干细胞的体外扩增。
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Characterization of ex vivo cultured limbal, conjunctival, and oral mucosal cells: A comparative study with implications in transplantation medicine.体外培养的角膜缘、结膜和口腔黏膜细胞的特性：一项对移植医学有启示意义的比较研究。
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[Long-term results of autologous transplantation of limbal epithelium cultivated ex vivo for limbal stem cell deficiency].[体外培养角膜缘上皮自体移植治疗角膜缘干细胞缺乏的长期结果]
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Clin Exp Ophthalmol. 2012 Apr;40(3):255-67. doi: 10.1111/j.1442-9071.2011.02609.x. Epub 2011 Aug 3.

引用本文的文献

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Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis.干眼症在小鼠中激活适应性角膜上皮再生，与体内平衡中的组成性更新不同。
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2204134120. doi: 10.1073/pnas.2204134120. Epub 2023 Jan 3.
2
Transplantation of tissue-engineered human corneal epithelium in limbal stem cell deficiency rabbit models.组织工程化人角膜上皮在角膜缘干细胞缺乏兔模型中的移植
Int J Ophthalmol. 2012;5(4):424-9. doi: 10.3980/j.issn.2222-3959.2012.04.04. Epub 2012 Aug 18.
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In vitro reconstruction and characterization of tissue-engineered human corneal epithelium with seeder cells from an untransfected human corneal epithelial cell line.利用未转染的人角膜上皮细胞系的种子细胞进行组织工程化人角膜上皮的体外重建与表征。
Int J Ophthalmol. 2012;5(3):281-5. doi: 10.3980/j.issn.2222-3959.2012.03.06. Epub 2012 Jun 18.

本文引用的文献

1
Mesenchymal stem cells and potential applications in treating ocular disease.间充质干细胞及其在眼部疾病治疗中的潜在应用。
Curr Eye Res. 2010 Nov;35(11):941-52. doi: 10.3109/02713683.2010.516466.
2
A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study.用于诱导角膜再生的人源供体组织的生物合成替代物：1 期临床研究的 24 个月随访结果。
Sci Transl Med. 2010 Aug 25;2(46):46ra61. doi: 10.1126/scitranslmed.3001022.
3
Management of ocular stem cell disease.
Int Ophthalmol Clin. 2010 Summer;50(3):25-34. doi: 10.1097/IIO.0b013e3181e20d64.
4
Limbal stem-cell therapy and long-term corneal regeneration.角膜缘干细胞治疗与长期角膜再生。
N Engl J Med. 2010 Jul 8;363(2):147-55. doi: 10.1056/NEJMoa0905955. Epub 2010 Jun 23.
5
Stem cell therapies for ocular surface disease.干细胞疗法治疗眼表疾病。
Drug Discov Today. 2010 Apr;15(7-8):306-13. doi: 10.1016/j.drudis.2010.02.001. Epub 2010 Feb 10.
6
Cornea and ocular surface treatment.角膜和眼表面治疗。
Curr Stem Cell Res Ther. 2010 Jun;5(2):195-204. doi: 10.2174/157488810791268663.
7
In sickness and in health: Corneal epithelial stem cell biology, pathology and therapy.生老病死：角膜上皮干细胞的生物学、病理学和治疗学。
Exp Eye Res. 2010 Feb;90(2):188-95. doi: 10.1016/j.exer.2009.09.023. Epub 2009 Oct 17.
8
A contact lens-based technique for expansion and transplantation of autologous epithelial progenitors for ocular surface reconstruction.一种基于隐形眼镜的自体上皮祖细胞扩增与移植技术用于眼表重建
Transplantation. 2009 May 27;87(10):1571-8. doi: 10.1097/TP.0b013e3181a4bbf2.
9
Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.人胚胎干细胞来源的光感受器移植可恢复Crx缺陷小鼠的部分视觉功能。
Cell Stem Cell. 2009 Jan 9;4(1):73-9. doi: 10.1016/j.stem.2008.10.015.
10
Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells.角膜缘微环境可诱导毛囊干细胞转分化为角膜上皮样细胞。
Stem Cells. 2009 Mar;27(3):642-52. doi: 10.1634/stemcells.2008-0721.