Department of Public Health and Community Medicine, University of Gothenburg, 405 30, Gothenburg, Sweden.
Obesity (Silver Spring). 2014 Mar;22(3):957-63. doi: 10.1002/oby.20604. Epub 2013 Sep 20.
Accumulating evidence consistently shows that small hip circumference (HC) is related to increased risk of cardiovascular disease (CVD), coronary heart disease, diabetes, and premature death in women. This study aims to clarify whether this inverse association can be found in both normal- and overweight individuals and if change in HC over time relates to morbidity and mortality risk.
HC and 6-year change in HC in relation to the risk for all-cause mortality and CVD morbidity and mortality was investigated in a pooled sample of 2,867 women from the DANISH MONICA study and the Prospective Population Study of Women in Gothenburg with a total of 66,627 person-years of follow-up.
Baseline HC was significantly and inversely associated with all-cause and CVD-specific mortality after adjustment for BMI, waist circumference (WC), and other covariates. In stratified analyses, the inverse association was weaker in women with a BMI of more than 25 kg/m2. Six-year change in hip size was not associated with mortality or morbidity endpoints.
Our results imply the existence of a basal risk associated with small hip size, which is, however, independent from changes in gluteofemoral body mass and therefore unlikely to be modifiable.
越来越多的证据表明,女性的小臀围(HC)与心血管疾病(CVD)、冠心病、糖尿病和早逝的风险增加有关。本研究旨在阐明这种反比关系是否在正常体重和超重个体中都能找到,如果 HC 随时间的变化与发病率和死亡率风险有关。
在丹麦 MONICA 研究和哥德堡前瞻性妇女人群研究的合并样本中,对 2867 名女性的 HC 和 6 年 HC 变化与全因死亡率和 CVD 发病率和死亡率的风险进行了研究,随访总人数为 66627 人年。
在调整 BMI、腰围(WC)和其他协变量后,基线 HC 与全因和 CVD 特异性死亡率呈显著负相关。在分层分析中,BMI 超过 25kg/m2 的女性中,这种反比关系较弱。6 年的臀围变化与死亡率或发病率终点无关。
我们的结果表明存在与小臀围相关的基础风险,但与臀腿部体质量的变化无关,因此不太可能是可改变的。