Benhadid-Brahmi Yasmine, Hamane Samia, Soyer Benjamin, Mebazaa Alexandre, Alanio Alexandre, Chousterman Benjamin, Bretagne Stéphane, Dellière Sarah
Université de Paris, Laboratoire de Parasitologie-Mycologie, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Université de Paris, FHU Promice, Département d'anesthésie-réanimation, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; INI-CRCT Network, Nancy, France; INSERM U942, Paris, France.
J Mycol Med. 2022 Mar;32(1):101231. doi: 10.1016/j.mycmed.2021.101231. Epub 2021 Nov 26.
COVID-19-associated mold infections have been increasingly reported, and the main entity is COVID-19-associated aspergillosis (CAPA). Similarly, COVID-19-associated mucormycosis has been reported in hematology, and its prevalence is high and has been increasing in the diabetic population in India during the third COVID-19 pandemic wave. Simultaneous infection with Mucorales and Aspergillus is rare and even rarer during COVID-19. Here, we report the case of a previously immunocompetent patient with severe SARS-CoV-2 infection complicated with probable CAPA and mucormycosis co-infection. Specific diagnostic tools for mucormycosis are lacking, and this case highlights the advantages of analyzing blood and respiratory samples using the quantitative polymerase chain reaction to detect these fungi. We further reviewed the literature on mixed Aspergillus/Mucorales invasive fungal diseases to provide an overview of patients presenting with both fungi and to identify characteristics of this rare infection.
与新冠病毒相关的霉菌感染报告日益增多，主要类型是与新冠病毒相关的曲霉病（CAPA）。同样，血液学领域已报告了与新冠病毒相关的毛霉病，在印度第三波新冠疫情期间，其在糖尿病患者中的患病率很高且呈上升趋势。毛霉目真菌和曲霉同时感染较为罕见，在新冠病毒感染期间更是罕见。在此，我们报告一例既往免疫功能正常的患者，其感染严重急性呼吸综合征冠状病毒2后并发可能的CAPA和毛霉病合并感染。目前缺乏毛霉病的特异性诊断工具，该病例突出了使用定量聚合酶链反应分析血液和呼吸道样本以检测这些真菌的优势。我们进一步回顾了关于曲霉/毛霉目混合侵袭性真菌病的文献，以概述同时感染这两种真菌的患者情况，并确定这种罕见感染的特征。
