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p16INK4a in cellular senescence.

作者信息

Simboeck Elisabeth, Di Croce Luciano

机构信息

Centre for Genomic Regulation (CRG) and UPF, Dr.Aiguader 88, 08003 Barcelona, Spain;

出版信息

Aging (Albany NY). 2013 Aug;5(8):590-1. doi: 10.18632/aging.100592.

DOI:10.18632/aging.100592
PMID:23965734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3796211/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/674c/3796211/a879574ecef8/aging-05-590-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/674c/3796211/a879574ecef8/aging-05-590-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/674c/3796211/a879574ecef8/aging-05-590-g001.jpg

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2
Polycomb complexes in stem cells and embryonic development.多梳复合物在干细胞和胚胎发育中的作用。
Development. 2013 Jun;140(12):2525-34. doi: 10.1242/dev.091553.
3
Epigenetics and senescence: learning from the INK4-ARF locus.表观遗传学与衰老：从 INK4-ARF 基因座中学习。
小胶质细胞衰老导致衰老小鼠海马体中女性偏倚性神经炎症：对阿尔茨海默病的影响。
J Neuroinflammation. 2023 Aug 16;20(1):188. doi: 10.1186/s12974-023-02870-2.
4
p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.p53 调节左心室压力超负荷时成纤维细胞增殖和纤维化的程度。
Circ Res. 2023 Jul 21;133(3):271-287. doi: 10.1161/CIRCRESAHA.121.320324. Epub 2023 Jul 6.
5
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease.小胶质细胞衰老导致衰老小鼠海马体中女性偏向性神经炎症：对阿尔茨海默病的影响。
bioRxiv. 2023 Jun 1:2023.03.07.531562. doi: 10.1101/2023.03.07.531562.
6
Mismatch repair dependence of replication stress-associated DSB recognition and repair.复制应激相关双链断裂识别与修复的错配修复依赖性
Heliyon. 2019 Dec 24;5(12):e03057. doi: 10.1016/j.heliyon.2019.e03057. eCollection 2019 Dec.
7
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