细胞衰老中的p16INK4a - Suppr

Suppr

超能文献

p16INK4a in cellular senescence.

作者信息

Simboeck Elisabeth, Di Croce Luciano

机构信息

Centre for Genomic Regulation (CRG) and UPF, Dr.Aiguader 88, 08003 Barcelona, Spain;

出版信息

Aging (Albany NY). 2013 Aug;5(8):590-1. doi: 10.18632/aging.100592.

DOI:10.18632/aging.100592

PMID:23965734

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3796211/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/674c/3796211/a879574ecef8/aging-05-590-g001.jpg

相似文献

p16INK4a in cellular senescence.细胞衰老中的p16INK4a

Aging (Albany NY). 2013 Aug;5(8):590-1. doi: 10.18632/aging.100592.

Replicative senescence in human uroepithelial cells.人尿道上皮细胞中的复制性衰老

Adv Exp Med Biol. 1999;462:83-91. doi: 10.1007/978-1-4615-4737-2_7.

VentX trans-activates p53 and p16ink4a to regulate cellular senescence.VentX 可激活 p53 和 p16ink4a 以调节细胞衰老。

J Biol Chem. 2011 Apr 8;286(14):12693-701. doi: 10.1074/jbc.M110.206078. Epub 2011 Feb 16.

Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts.通过向人二倍体成纤维细胞直接添加触角足蛋白-p16INK4A融合蛋白诱导的复制性衰老的特征

FEBS Lett. 1998 May 8;427(2):203-8. doi: 10.1016/s0014-5793(98)00426-8.

High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea.p16INK4a的高表达和Bmi1的低表达与人角膜内皮细胞衰老相关。

Mol Vis. 2012;18:803-15. Epub 2012 Apr 3.

Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1.黑色素积累通过一种涉及p16INK4a/CDK4/pRB和E2F1的机制加速黑素细胞衰老。

Ann N Y Acad Sci. 2000 Jun;908:71-84. doi: 10.1111/j.1749-6632.2000.tb06637.x.

Oncogene-induced senescence pathways in melanocytes.

Cell Cycle. 2010 Dec 15;9(24):4778-9. doi: 10.4161/cc.9.24.14248.

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.细胞周期蛋白依赖性激酶抑制剂p21和p16在人成纤维细胞衰老和分化机制中的不同作用。

Mol Cell Biol. 1999 Mar;19(3):2109-17. doi: 10.1128/MCB.19.3.2109.

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.肿瘤抑制因子和衰老生物标志物 p16(INK4a) 在没有相关炎症分泌表型的情况下诱导细胞衰老。

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.

The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression.p16INK4a-RB 通路：细胞衰老与肿瘤抑制之间的分子联系。

J Med Invest. 2004 Aug;51(3-4):146-53. doi: 10.2152/jmi.51.146.

引用本文的文献

ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways.ABT263通过调节PI3K/AKT/GSK-3β信号通路改善老年APP/PS1小鼠的细胞衰老、Aβ相关病理变化及认知衰退。

Cell Biochem Biophys. 2025 Apr 28. doi: 10.1007/s12013-025-01745-y.

Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis.炎症与细胞衰老的相互作用：骨关节炎发生和进展的新见解

Bone Res. 2024 Dec 3;12(1):69. doi: 10.1038/s41413-024-00375-z.

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease.小胶质细胞衰老导致衰老小鼠海马体中女性偏倚性神经炎症：对阿尔茨海默病的影响。

J Neuroinflammation. 2023 Aug 16;20(1):188. doi: 10.1186/s12974-023-02870-2.

p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.p53 调节左心室压力超负荷时成纤维细胞增殖和纤维化的程度。

Circ Res. 2023 Jul 21;133(3):271-287. doi: 10.1161/CIRCRESAHA.121.320324. Epub 2023 Jul 6.

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease.小胶质细胞衰老导致衰老小鼠海马体中女性偏向性神经炎症：对阿尔茨海默病的影响。

bioRxiv. 2023 Jun 1:2023.03.07.531562. doi: 10.1101/2023.03.07.531562.

Mismatch repair dependence of replication stress-associated DSB recognition and repair.复制应激相关双链断裂识别与修复的错配修复依赖性

Heliyon. 2019 Dec 24;5(12):e03057. doi: 10.1016/j.heliyon.2019.e03057. eCollection 2019 Dec.

A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1.一种类似类固醇的植物化学物质安妥明M是一种抗衰老试剂，它通过直接激活Nrf2和SIRT-1来消除高血糖加速的皮肤成纤维细胞过早衰老。

Oncotarget. 2016 Sep 27;7(39):62836-62861. doi: 10.18632/oncotarget.11229.

ETV1 positively regulates transcription of tumor suppressor ARF.ETV1正向调控肿瘤抑制因子ARF的转录。

Cancer Biol Ther. 2013 Dec;14(12):1167-73. doi: 10.4161/cbt.26883. Epub 2013 Oct 23.

本文引用的文献

DPY30 regulates pathways in cellular senescence through ID protein expression.DPY30 通过 ID 蛋白表达调控细胞衰老途径。

EMBO J. 2013 Aug 14;32(16):2217-30. doi: 10.1038/emboj.2013.159. Epub 2013 Jul 19.

Polycomb complexes in stem cells and embryonic development.多梳复合物在干细胞和胚胎发育中的作用。

Development. 2013 Jun;140(12):2525-34. doi: 10.1242/dev.091553.

Epigenetics and senescence: learning from the INK4-ARF locus.表观遗传学与衰老：从 INK4-ARF 基因座中学习。

Biochem Pharmacol. 2011 Nov 15;82(10):1361-70. doi: 10.1016/j.bcp.2011.07.084. Epub 2011 Jul 22.

DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation.DDB1 - CUL4和MLL1介导癌基因诱导的p16INK4a激活。

Cancer Res. 2009 Mar 1;69(5):1809-14. doi: 10.1158/0008-5472.CAN-08-2739. Epub 2009 Feb 10.

Id family of helix-loop-helix proteins in cancer.癌症中螺旋-环-螺旋蛋白的Id家族。

Nat Rev Cancer. 2005 Aug;5(8):603-14. doi: 10.1038/nrc1673.

Id proteins in cell cycle control and cellular senescence.细胞周期调控与细胞衰老中的Id蛋白

Oncogene. 2001 Dec 20;20(58):8317-25. doi: 10.1038/sj.onc.1205092.

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.Ets蛋白和Id蛋白在细胞衰老过程中对p16INK4a表达的相反作用。

Nature. 2001 Feb 22;409(6823):1067-70. doi: 10.1038/35059131.

Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1.显性负性螺旋-环-螺旋蛋白Id1的转录受一种包含即刻早期反应基因Egr-1的蛋白复合物调控。

Mol Cell Biol. 1996 May;16(5):2418-30. doi: 10.1128/MCB.16.5.2418.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验