TMPRSS2 是呼吸道副流感病毒的一种激活蛋白酶。
TMPRSS2 is an activating protease for respiratory parainfluenza viruses.
机构信息
Department of Virology 3.
出版信息
J Virol. 2013 Nov;87(21):11930-5. doi: 10.1128/JVI.01490-13. Epub 2013 Aug 21.
Abstract
Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.
摘要
在这里，我们表明人类副流感病毒和仙台病毒（SeV）与其他呼吸道病毒一样，利用 TMPRSS2 进行激活。呼吸道病毒的膜融合蛋白通常在 P2 和 P3 位置分别具有丝氨酸和谷氨酰胺残基，但这些残基对于 TMPRSS2 的切割不是关键的。然而，这些残基的突变影响了 SeV 在特定上皮细胞系中的生长，表明这些残基对于 SeV 在上皮细胞中的复制很重要。
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