伊朗卡尚1至15岁儿童中抗甲型肝炎抗体的血清流行率
Seroprevalence of anti-hepatitis a antibody among 1 - 15 year old children in kashan-iran.
作者信息
Taghavi Ardakani Abbas, Soltani Babak, Sehat Mojtaba, Namjoo Somayeh, Haji Rezaei Mostafa
机构信息
Department of Pediatrics, Kashan University of Medical Sciences, Kashan, IR Iran.
出版信息
Hepat Mon. 2013 May 27;13(5):e10553. doi: 10.5812/hepatmon.10553. eCollection 2013 May.
BACKGROUND
Worldwide, hepatitis A is a common infection during childhood especially in developing countries. It can cause severe complications in adults and patients with underlying diseases.
OBJECTIVES
This study was performed to determine the seroprevalence of hepatitis A in 1 - 15 year-old children of Kashan.
PATIENTS AND METHODS
This cross-sectional study was performed on 666 one to fifteen year-old children from health-care centers in Kashan city during 2012. Total antibodies against hepatitis A were measured in sera by enzyme-linked immunosorbent assay (ELISA).
RESULTS
Totally, 3.9% of children were seropositive. Mean number of family members was 3.92 ± 0.89. There was no difference in seroprevalence of hepatitis A relative to sex, family size, mean age and age groups.
CONCLUSIONS
In this city, a great proportion of children are susceptible to hepatitis A and it's complications at an older age. This decrease in seropositivity may be caused by elevated hygien level. According to our results hepatitis A vaccination is recommended at early childhood such as that of other regions where low prevalence of hepatitis A infection is found.
背景
在全球范围内，甲型肝炎是儿童期常见的感染性疾病，尤其在发展中国家。它可在成人及患有基础疾病的患者中引发严重并发症。
目的
本研究旨在确定卡尚市1至15岁儿童中甲肝的血清流行率。
患者与方法
本横断面研究于2012年对卡尚市医疗保健中心的666名1至15岁儿童进行。采用酶联免疫吸附测定法（ELISA）检测血清中甲肝总抗体。
结果
总计3.9%的儿童血清学阳性。家庭成员平均数量为3.92±0.89。甲肝血清流行率在性别、家庭规模、平均年龄及年龄组方面无差异。
结论
在本市，很大一部分儿童在较大年龄时仍易患甲型肝炎及其并发症。血清学阳性率的下降可能是卫生水平提高所致。根据我们的研究结果，建议在幼儿期进行甲肝疫苗接种，如同在其他甲型肝炎感染率低的地区一样。
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