Taghavi Ardakani Abbas, Soltani Babak, Sehat Mojtaba, Namjoo Somayeh, Haji Rezaei Mostafa
Department of Pediatrics, Kashan University of Medical Sciences, Kashan, IR Iran.
Hepat Mon. 2013 May 27;13(5):e10553. doi: 10.5812/hepatmon.10553. eCollection 2013 May.
Worldwide, hepatitis A is a common infection during childhood especially in developing countries. It can cause severe complications in adults and patients with underlying diseases.
This study was performed to determine the seroprevalence of hepatitis A in 1 - 15 year-old children of Kashan.
This cross-sectional study was performed on 666 one to fifteen year-old children from health-care centers in Kashan city during 2012. Total antibodies against hepatitis A were measured in sera by enzyme-linked immunosorbent assay (ELISA).
Totally, 3.9% of children were seropositive. Mean number of family members was 3.92 ± 0.89. There was no difference in seroprevalence of hepatitis A relative to sex, family size, mean age and age groups.
In this city, a great proportion of children are susceptible to hepatitis A and it's complications at an older age. This decrease in seropositivity may be caused by elevated hygien level. According to our results hepatitis A vaccination is recommended at early childhood such as that of other regions where low prevalence of hepatitis A infection is found.
在全球范围内，甲型肝炎是儿童期常见的感染性疾病，尤其在发展中国家。它可在成人及患有基础疾病的患者中引发严重并发症。
本研究旨在确定卡尚市1至15岁儿童中甲肝的血清流行率。
本横断面研究于2012年对卡尚市医疗保健中心的666名1至15岁儿童进行。采用酶联免疫吸附测定法（ELISA）检测血清中甲肝总抗体。
总计3.9%的儿童血清学阳性。家庭成员平均数量为3.92±0.89。甲肝血清流行率在性别、家庭规模、平均年龄及年龄组方面无差异。
在本市，很大一部分儿童在较大年龄时仍易患甲型肝炎及其并发症。血清学阳性率的下降可能是卫生水平提高所致。根据我们的研究结果，建议在幼儿期进行甲肝疫苗接种，如同在其他甲型肝炎感染率低的地区一样。
