Karimi Ali, Mortazaei Seifollah, Moradi Mohammad-Taghi
Associate Professor, Department of Virology, Cellular and Molecular Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran .
PhD Student, Department of Virology, Medical Plants Research Center, Shahrekord University of Medical Science , Shahrekord, Iran .
J Clin Diagn Res. 2015 Feb;9(2):DC01-3. doi: 10.7860/JCDR/2015/9798.5515. Epub 2015 Feb 1.
Hepatitis A virus (HAV) is the most common cause of hepatitis during childhood and is an important public health problem. Therefore, the aim of this study was to investigate an outbreak of symptomatic viral hepatitis in children and in young adults in a rural area from Chaharmahal Va Bakhtiari Province, Iran.
Serum samples from the 70 patients with icterus, who were suspected for HAV infection, referred to a therapeutic center in a central province of Iran from February to July, 2010 were tested for IgM specific antibody to HAV, using Enzyme linked Fluorscent assay (ELFA) Kit (General Biological Corp., Hsinchu, Taiwan).
All of the 70 children had jaundice. The ELFA results showed that 48 out of 70 (68.6%) tested positive for anti-HAV specific antibody (IgM). The mean age of the individuals were 12.81+12.2 and 23 of them (32.8%) were females. There was significant relationship between seropositivity for IgM anti-HAV antibody and age group in the patients studied (p<0.05).
The high number of cases identified, may indicate an outbreak of hepatitis A in this region with the children as the most susceptible age group to this symptomatic infection.
甲型肝炎病毒（HAV）是儿童期肝炎最常见的病因，也是一个重要的公共卫生问题。因此，本研究旨在调查伊朗恰哈马哈勒-巴赫蒂亚里省一个农村地区儿童和青年中症状性病毒性肝炎的暴发情况。
2010年2月至7月，将70例疑似HAV感染的黄疸患者的血清样本送至伊朗中部省份的一个治疗中心，使用酶联荧光分析法（ELFA）试剂盒（台湾新竹通用生物公司）检测甲型肝炎病毒特异性IgM抗体。
所有70名儿童均出现黄疸。ELFA结果显示，70例中有48例（68.6%）抗HAV特异性抗体（IgM）检测呈阳性。患者的平均年龄为12.81±12.2岁，其中23例（32.8%）为女性。在所研究的患者中，IgM抗HAV抗体血清阳性与年龄组之间存在显著关系（p<0.05）。
确诊的大量病例可能表明该地区发生了甲型肝炎暴发，儿童是这种症状性感染最易感的年龄组。
