Department of Bacteriology and Virology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
PLoS One. 2010 Mar 22;5(3):e9645. doi: 10.1371/journal.pone.0009645.
The bacterium Helicobacter pylori colonizes the human stomach, with individual infections persisting for decades. The spread of the bacterium has been shown to reflect both ancient and recent human migrations. We have sequenced housekeeping genes from H. pylori isolated from 147 Iranians with well-characterized geographical and ethnic origins sampled throughout Iran and compared them with sequences from strains from other locations. H. pylori from Iran are similar to others isolated from Western Eurasia and can be placed in the previously described HpEurope population. Despite the location of Iran at the crossroads of Eurasia, we found no evidence that the region been a major source of ancestry for strains across the continent. On a smaller scale, we found genetic affinities between the H. pylori isolated from particular Iranian populations and strains from Turks, Uzbeks, Palestinians and Israelis, reflecting documented historical contacts over the past two thousand years.
幽门螺旋杆菌定植于人类胃部，个体感染可持续数十年。该细菌的传播既反映了古代人类迁徙，也反映了近期人类迁徙。我们对从伊朗 147 名具有明确地理和民族起源的个体中分离出的幽门螺旋杆菌的管家基因进行了测序，并将其与来自其他地区的菌株序列进行了比较。伊朗的幽门螺旋杆菌与从西欧分离出的菌株相似，可以归入先前描述的 HpEurope 种群。尽管伊朗地处欧亚大陆的十字路口，但我们没有发现该地区曾是整个大陆菌株主要起源地的证据。在较小的范围内，我们发现从伊朗特定人群中分离出的幽门螺旋杆菌与土耳其人、乌兹别克人、巴勒斯坦人和以色列人的菌株存在遗传亲和力，这反映了过去两千年来有记录的历史接触。
