Malouf R, Jacquette G, Dobkin J, Brust J C
Department of Neurology, Harlem Hospital Center, New York, NY 10037.
Arch Neurol. 1990 Sep;47(9):1002-7. doi: 10.1001/archneur.1990.00530090076016.
Previous studies of human immuno-deficiency virus-related neurologic disease have been either retrospective or have included mostly homosexual patients. We sought to determine (1) the true prevalence of neurologic abnormalities in patients with acquired immunodeficiency syndrome or lymphadenopathy acquired immunodeficiency-related complex, and (2) whether differences in prevalence or type of neurological abnormality exist between parenteral drug abusers and non-parenteral drug abusers. We prospectively evaluated 190 adult inpatients with either acquired immunodeficiency syndrome (129) or lymphadenopathy acquired immunodeficiency-related complex (61); 151 (80%) were parenteral drug abusers, and 172 patients (91%) had neurologic symptoms or signs. There was no significant difference in prevalence of neurologic disease between parenteral drug abusers and non-parenteral drug abusers, or between patients with acquired immunodeficiency syndrome and those with lymphadenopathy acquired immunodeficiency-related complex. The prevalence of neurologic symptoms in these patients with lymphadenopathy acquired immunodeficiency-related complex and acquired immunodeficiency syndrome is the highest reported to date and appears to reflect the prospective nature of the study.
先前关于人类免疫缺陷病毒相关神经疾病的研究要么是回顾性的，要么主要纳入的是同性恋患者。我们试图确定：（1）获得性免疫缺陷综合征或淋巴结病相关的免疫缺陷综合征患者中神经异常的真实患病率；（2）静脉药物滥用者与非静脉药物滥用者在神经异常患病率或类型上是否存在差异。我们对190名成年住院患者进行了前瞻性评估，这些患者患有获得性免疫缺陷综合征（129例）或淋巴结病相关的免疫缺陷综合征（61例）；其中151例（80%）为静脉药物滥用者，172例患者（91%）有神经症状或体征。静脉药物滥用者与非静脉药物滥用者之间，以及获得性免疫缺陷综合征患者与淋巴结病相关的免疫缺陷综合征患者之间，神经疾病的患病率没有显著差异。这些淋巴结病相关的免疫缺陷综合征和获得性免疫缺陷综合征患者的神经症状患病率是迄今为止报告的最高值，这似乎反映了该研究的前瞻性特点。
