Leevy C B, Nurse H, Kapila R
J Assoc Acad Minor Phys. 1989;1(1):18-9, 22-3.
Eighty-percent of 47 parenteral drug abusers with hepatomegaly and acquired immunodeficiency syndrome had HBV DNA in serum, although only 27% were HBsAg or "e" antigen-positive by polyclonal radioimmunoassay. Liver biopsies from each of 37 HBV DNA seropositive patients showed HBV DNA and were HBcAg-positive. The absence of positive HBsAg and "e" antigen in HBV DNA-positive patients was attributable to the presence of immune complexes; after in vitro dissociation of these complexes there was an increase in HBsAg from 24% to 86%, and of "e" antigen from 19% to 62%. These data indicate that actively replicating hepatitis B virus is common in patients with AIDS, and that precautions should be taken to prevent its dissemination. Therapy in these patients should address both human immunodeficiency and hepatitis B virus infections.
47名患有肝肿大和获得性免疫缺陷综合征的静脉注射毒品成瘾者中，80%的患者血清中有乙肝病毒脱氧核糖核酸（HBV DNA），尽管通过多克隆放射免疫测定法只有27%的患者乙肝表面抗原（HBsAg）或“e”抗原呈阳性。37名HBV DNA血清反应阳性患者的肝活检显示有HBV DNA且乙肝核心抗原（HBcAg）呈阳性。HBV DNA阳性患者中HBsAg和“e”抗原呈阴性是由于存在免疫复合物；这些复合物在体外解离后，HBsAg阳性率从24%升至86%，“e”抗原阳性率从19%升至62%。这些数据表明，艾滋病患者中乙肝病毒活跃复制的情况很常见，应采取预防措施防止其传播。对这些患者的治疗应兼顾人类免疫缺陷病毒感染和乙肝病毒感染。
