Vitalis D
Department of Infection and Population Health, Royal Free Hospital & Medical School, University College London, Upper 3rd Floor, Rowland Hill Street, London NW3 2PF, UK.
Int J STD AIDS. 2013 Jun;24(6):427-32. doi: 10.1177/0956462412472807. Epub 2013 Jul 19.
Adherence to antiretroviral therapy (ART) is crucial for effective treatment, but can be quite complex. Non-adherence can adversely affect treatment outcomes. Although many studies have been done on adherence in the general population, few have included HIV-positive pregnant and postpartum women in resource-constrained settings. This review assessed the evidence on adherence among these groups of women. A systematic search of databases was completed between June and July 2011. Both qualitative and quantitative studies were included. Eighteen studies from a total of 6622 satisfied the inclusion criteria that included inter alia facilitators and barriers to adherence. This review highlighted that there is still no consensus on the definition and measurement of adherence; also multiple factors can affect a woman's ability to adhere to ART. Some of the barriers and facilitators identified were similar in both the type of study (qualitative and quantitative) and among the various countries. Findings indicated that the few studies in this population are conducted primarily in resource-rich settings. Such paucity of information warrants urgent attention; thus targeted research is needed to provide insight on adherence within this population.
坚持抗逆转录病毒疗法（ART）对于有效治疗至关重要，但可能相当复杂。不坚持治疗会对治疗结果产生不利影响。尽管针对普通人群的坚持治疗情况已开展了许多研究，但在资源有限的环境中，很少有研究纳入HIV阳性的孕妇和产后妇女。本综述评估了这些女性群体中关于坚持治疗的证据。2011年6月至7月间完成了对数据库的系统检索。纳入了定性和定量研究。总共6622项研究中的18项符合纳入标准，这些标准尤其包括坚持治疗的促进因素和障碍。本综述强调，在坚持治疗的定义和衡量方面仍未达成共识；此外，多种因素会影响女性坚持ART治疗的能力。在研究类型（定性和定量）以及不同国家中，所确定的一些障碍和促进因素是相似的。研究结果表明，针对这一人群的研究很少主要在资源丰富的环境中进行。如此匮乏的信息值得紧急关注；因此，需要开展针对性研究，以深入了解这一人群的坚持治疗情况。
